MTHFR antibody (AA 266-292)

Catalog No. ABIN1881559

Product Details anti-MTHFR Antibody

Target: MTHFR (Methylenetetrahydrofolate Reductase (NAD(P)H) (MTHFR))

Binding Specificity: AA 266-292

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MTHFR antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: B, Pr, M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This MTHFR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 266-292 amino acids from the Central region of human MTHFR.

Clone: RB41196

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-MTHFR antibody (ABIN1881559)

Singh, Singh, Raman: "MTHFR A1298C polymorphism and idiopathic male infertility." in: Journal of postgraduate medicine, Vol. 56, Issue 4, pp. 267-9, (2010) (PubMed).

Harisha, Devi, Christopher, Kruthika-Vinod: "Impact of 5,10-methylenetetrahydrofolate reductase gene polymorphism on neural tube defects." in: Journal of neurosurgery. Pediatrics, Vol. 6, Issue 4, pp. 364-7, (2010) (PubMed).

Wu, Chang, Tsai, Lin, Wang, Tsai, Chen, Yao, Chiu, Bau, Lin: "Significant association of methylenetetrahydrofolate reductase single nucleotide polymorphisms with prostate cancer susceptibility in taiwan." in: Anticancer research, Vol. 30, Issue 9, pp. 3573-7, (2010) (PubMed).

Magnowski, Seremak-Mrozikiewicz, Nowak-Markwitz, Kurzawińska, Drews, Spaczyński: "[No association between MTHFR 677C>T polymorphism and ovarian cancer risk in BRCA1 mutation carriers in Wielkopolska region]." in: Ginekologia polska, Vol. 81, Issue 7, pp. 506-10, (2010) (PubMed).

Kristensen, Pedersen, Melsen, Ellehauge, Mejer: "Variants in the dihydropyrimidine dehydrogenase, methylenetetrahydrofolate reductase and thymidylate synthase genes predict early toxicity of 5-fluorouracil in colorectal cancer patients." in: The Journal of international medical research, Vol. 38, Issue 3, pp. 870-83, (2010) (PubMed).

Target Details for MTHFR

Target: MTHFR (Methylenetetrahydrofolate Reductase (NAD(P)H) (MTHFR))

Alternative Name: MTHFR (MTHFR Products)

Synonyms: DDBDRAFT_0204686 antibody, DDBDRAFT_0230137 antibody, DDB_0204686 antibody, DDB_0230137 antibody, AI323986 antibody, methylenetetrahydrofolate reductase (NAD(P)H) L homeolog antibody, methylenetetrahydrofolate reductase antibody, methylenetetrahydrofolate reductase (NAD(P)H) antibody, 5,10-methylenetetrahydrofolate reductase antibody, mthfr.L antibody, MTHFR antibody, mthfr antibody, metF antibody, DDB_G0279137 antibody, Mthfr antibody

Background: The protein encoded by this gene catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency.

Molecular Weight: 74597

NCBI Accession: NP_005948

UniProt: P42898

Pathways: Methionine Biosynthetic Process