MTAP antibody (N-Term)

Catalog No. ABIN1881557

Product Details anti-MTAP Antibody

Target: MTAP (Methylthioadenosine phosphorylase (MTAP))

Binding Specificity: AA 8-37, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MTAP antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: B, M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This MTAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-37 amino acids from the N-terminal region of human MTAP.

Clone: RB42759

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-MTAP antibody (ABIN1881557)

Newton-Bishop, Chang, Iles, Taylor, Bakker, Chan, Leake, Karpavicius, Haynes, Fitzgibbon, Elliott, Kanetsky, Harland, Barrett, Bishop: "Melanocytic nevi, nevus genes, and melanoma risk in a large case-control study in the United Kingdom." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 8, pp. 2043-54, (2010) (PubMed).

Zhang, Cheng, Yan, Chen, Wang, Yang: "[Association between methylthioadenosine phosphorylase gene single nucleotide polymorphisms and myocardial infarction in Chinese Han ethnicity]." in: Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi, Vol. 31, Issue 1, pp. 83-6, (2010) (PubMed).

Huang, Li, Yu, Chou, Tzeng, Hu, Uen, Tian, Wang, Fang, Huang, Wei, Wu, Li: "Homozygous deletion of MTAP gene as a poor prognosticator in gastrointestinal stromal tumors." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 22, pp. 6963-72, (2009) (PubMed).

Target Details for MTAP

Target: MTAP (Methylthioadenosine phosphorylase (MTAP))

Alternative Name: MTAP (MTAP Products)

Synonyms: BDMF antibody, DMSFH antibody, DMSMFH antibody, LGMBF antibody, MSAP antibody, c86fus antibody, Cc1-6 antibody, 1300019I21Rik antibody, MTAPase antibody, zgc:66012 antibody, mtap antibody, methylthioadenosine phosphorylase antibody, 5'-methylthioadenosine phosphorylase antibody, 6-oxopurine nucleoside phosphorylase antibody, methylthioadenosine phosphorylase L homeolog antibody, MTAP antibody, Mtap antibody, mtaP antibody, MMAH_RS04260 antibody, TAGG_RS05050 antibody, Toce_0364 antibody, VDIS_RS03165 antibody, MFER_RS02485 antibody, Intca_0886 antibody, DESMU_RS05370 antibody, Dester_1490 antibody, ARCVE_RS05445 antibody, Mahau_1873 antibody, MZHIL_RS01440 antibody, mtap antibody, mtap.L antibody

Background: This gene encodes an enzyme that plays a major role in polyamine metabolism and is important for the salvage of both adenine and methionine. The encoded enzyme is deficient in many cancers because this gene and the tumor suppressor p16 gene are co-deleted. Multiple alternatively spliced transcript variants have been described for this gene, but their full-length natures remain unknown.

Molecular Weight: 31236

NCBI Accession: NP_002442

UniProt: Q13126

Pathways: Ribonucleoside Biosynthetic Process, Methionine Biosynthetic Process