MMEL1 antibody (N-Term)

Catalog No. ABIN1881545

Product Details anti-MMEL1 Antibody

Target: MMEL1 (Membrane Metallo-Endopeptidase-Like 1 (MMEL1))

Binding Specificity: AA 50-78, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MMEL1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This MMEL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 50-78 amino acids from the N-terminal region of human MMEL1.

Clone: RB40353

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-MMEL1 antibody (ABIN1881545)

van der Helm-van Mil, Toes, Huizinga: "Genetic variants in the prediction of rheumatoid arthritis." in: Annals of the rheumatic diseases, Vol. 69, Issue 9, pp. 1694-6, (2010) (PubMed).

Hirschfield, Liu, Han, Gorlov, Lu, Xu, Lu, Chen, Juran, Coltescu, Mason, Milkiewicz, Myers, Odin, Luketic, Speiciene, Vincent, Levy, Gregersen, Zhang, Heathcote, Lazaridis, Amos, Siminovitch: "Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis." in: Nature genetics, Vol. 42, Issue 8, pp. 655-7, (2010) (PubMed).

Stahl, Raychaudhuri, Remmers, Xie, Eyre, Thomson, Li, Kurreeman, Zhernakova, Hinks, Guiducci, Chen, Alfredsson, Amos, Ardlie, Barton, Bowes, Brouwer, Burtt, Catanese, Coblyn, Coenen et al.: "Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci...." in: Nature genetics, Vol. 42, Issue 6, pp. 508-14, (2010) (PubMed).

Dubois, Trynka, Franke, Hunt, Romanos, Curtotti, Zhernakova, Heap, Adány, Aromaa, Bardella, van den Berg, Bockett, de la Concha, Dema, Fehrmann, Fernández-Arquero, Fiatal, Grandone, Green, Groen et al.: "Multiple common variants for celiac disease influencing immune gene expression. ..." in: Nature genetics, Vol. 42, Issue 4, pp. 295-302, (2010) (PubMed).

Target Details for MMEL1

Target: MMEL1 (Membrane Metallo-Endopeptidase-Like 1 (MMEL1))

Alternative Name: MMEL1 (MMEL1 Products)

Synonyms: MMEL2 antibody, NEP2 antibody, NEPII antibody, NL1 antibody, NL2 antibody, SEP antibody, Mell1 antibody, Nl1 antibody, MMEL1 antibody, membrane metalloendopeptidase like 1 antibody, membrane metallo-endopeptidase-like 1 antibody, MMEL1 antibody, Mmel1 antibody, mmel1 antibody

Background: The protein encoded by this gene is a member of the neutral endopeptidase (NEP) or membrane metallo-endopeptidase (MME) family. Family members play important roles in pain perception, arterial pressure regulation, phosphate metabolism and homeostasis. This protein is a type II transmembrane protein and is thought to be expressed as a secreted protein. This gene is expressed mainly in testis with weak expression in the brain, kidney, and heart.

Molecular Weight: 89367

NCBI Accession: NP_258428

UniProt: Q495T6