MEFV antibody (AA 418-445)

Catalog No. ABIN1881537

Product Details anti-MEFV Antibody

Target: MEFV (Mediterranean Fever (MEFV))

Binding Specificity: AA 418-445

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MEFV antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This MEFV antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 418-445 amino acids from the Central region of human MEFV.

Clone: RB41739

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-MEFV antibody (ABIN1881537)

Cosan, Ustek, Oku, Duymaz-Tozkir, Cakiris, Abaci, Ocal, Aral, Gül: "Association of familial Mediterranean fever-related MEFV variations with ankylosing spondylitis." in: Arthritis and rheumatism, Vol. 62, Issue 11, pp. 3232-6, (2010) (PubMed).

He, Lu, Kang, Luan, Liu, Yin, Yao, Ding, Li, Heng: "MEFV E148Q polymorphism is associated with Henoch-Schönlein purpura in Chinese children." in: Pediatric nephrology (Berlin, Germany), Vol. 25, Issue 10, pp. 2077-82, (2010) (PubMed).

Shimada, Miyagawa, Kawashima, Tanaka, Honda, Honda, Tokunaga: "An approach based on a genome-wide association study reveals candidate loci for narcolepsy." in: Human genetics, Vol. 128, Issue 4, pp. 433-41, (2010) (PubMed).

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, (2010) (PubMed).

Target Details for MEFV

Target: MEFV (Mediterranean Fever (MEFV))

Alternative Name: MEFV (MEFV Products)

Synonyms: pyrin antibody, MEFV antibody, FMF antibody, MEF antibody, TRIM20 antibody, rfp domain antibody, MEFV, pyrin innate immunity regulator antibody, Mediterranean fever antibody, MEFV antibody, Mefv antibody

Background: This gene encodes a protein, also known as pyrin or marenostrin, that is an important modulator of innate immunity. Mutations in this gene are associated with Mediterranean fever, a hereditary periodic fever syndrome.

Molecular Weight: 86444

NCBI Accession: NP_000234, NP_001185465

UniProt: O15553

Pathways: Positive Regulation of Endopeptidase Activity