GPR68 antibody (AA 200-225)

Catalog No. ABIN1881516

Product Details anti-GPR68 Antibody

Target: GPR68 (G Protein-Coupled Receptor 68 (GPR68))

Binding Specificity: AA 200-225

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GPR68 antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: B, H

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Mouse Gpr68 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 200-225 amino acids from the Central region of mouse Gpr68.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-GPR68 antibody (ABIN1881516)

Frick, Krieger, Nehrke, Bushinsky: "Metabolic acidosis increases intracellular calcium in bone cells through activation of the proton receptor OGR1." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 24, Issue 2, pp. 305-13, (2009) (PubMed).

Singh, Berk, Oates, Zhao, Tan, Jiang, Zhou, Kirmani, Steinmetz, Lindner, Xu: "Ovarian cancer G protein-coupled receptor 1, a new metastasis suppressor gene in prostate cancer." in: Journal of the National Cancer Institute, Vol. 99, Issue 17, pp. 1313-27, (2007) (PubMed).

Target Details for GPR68

Target: GPR68 (G Protein-Coupled Receptor 68 (GPR68))

Alternative Name: Gpr68 (GPR68 Products)

Synonyms: GPR68 antibody, GPR12A antibody, OGR1 antibody, BB131428 antibody, Ogr1 antibody, G protein-coupled receptor 68 antibody, GPR68 antibody, LOC100348269 antibody, Gpr68 antibody

Background: Proton-sensing receptor involved in pH homeostasis. May represents an osteoblastic pH sensor regulating cell-mediated responses to acidosis in bone. Mediates its action by association with G proteins that stimulates inositol phosphate (IP) production or Ca(2+) mobilization. The receptor is almost silent at pH 7.8 but fully activated at pH 6.8. Function also as a metastasis suppressor gene in prostate cancer.

Molecular Weight: 41209

NCBI Accession: NP_001171144, NP_001171145, NP_780702

UniProt: Q8BFQ3