LONP1 antibody (AA 389-418)

Catalog No. ABIN1881504

Product Details anti-LONP1 Antibody

Target: LONP1 (Lon Peptidase 1, Mitochondrial (LONP1))

Binding Specificity: AA 389-418

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LONP1 antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: B, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This LONP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 389-418 amino acids from the Central region of human LONP1.

Clone: RB40823

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000. WB: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-LONP1 antibody (ABIN1881504)

Merra, Lago, Ricci, Antuzzi, Gasbarrini, Gasbarrini, Ghirlanda: "Splenomegaly as a primary manifestation of Gaucher disease in a young adult woman." in: Case reports in gastroenterology, Vol. 2, Issue 3, pp. 474-8, (2011) (PubMed).

Chen, Suzuki, Wu: "Thermodynamic characterization of specific interactions between the human Lon protease and G-quartet DNA." in: Nucleic acids research, Vol. 36, Issue 4, pp. 1273-87, (2008) (PubMed).

Bayot, Basse, Lee, Gareil, Pirotte, Bulteau, Friguet, Reboud-Ravaux: "Towards the control of intracellular protein turnover: mitochondrial Lon protease inhibitors versus proteasome inhibitors." in: Biochimie, Vol. 90, Issue 2, pp. 260-9, (2008) (PubMed).

Bogenhagen, Rousseau, Burke: "The layered structure of human mitochondrial DNA nucleoids." in: The Journal of biological chemistry, Vol. 283, Issue 6, pp. 3665-75, (2008) (PubMed).

Xue, Zhu, Mao: "[Effect of RNA interference for Lon gene silencing on growth and apoptosis of human breast cancer MCF7 cells]." in: Nan fang yi ke da xue xue bao = Journal of Southern Medical University, Vol. 27, Issue 6, pp. 870-4, (2007) (PubMed).

Target Details for LONP1

Target: LONP1 (Lon Peptidase 1, Mitochondrial (LONP1))

Alternative Name: LONP1 (LONP1 Products)

Synonyms: PRSS15 antibody, prss15 antibody, fc64d11 antibody, wu:fc64d11 antibody, LON antibody, LONP antibody, LonHS antibody, PIM1 antibody, hLON antibody, 1200017E13Rik antibody, Prss15 antibody, Lon antibody, lon peptidase 1, mitochondrial antibody, ATP-dependent Lon protease antibody, LONP1 antibody, lonp1 antibody, Lonp1 antibody, PIM1 antibody

Background: This gene encodes a mitochondrial matrix protein in the Lon family of ATP-dependent proteases. A similar E. coli protein regulates gene expression by targeting specific regulatory proteins for degradation. This protein binds a specific sequence in the light and heavy chain promoters of the mitochondrial genome which are involved in regulation of DNA replication and transcription.

Molecular Weight: 106489

NCBI Accession: NP_001263408, NP_001263409, NP_004784

UniProt: P36776