LIN7B antibody (N-Term)

Catalog No. ABIN1881500

Product Details anti-LIN7B Antibody

Target: LIN7B (Lin-7 Homolog B (LIN7B))

Binding Specificity: AA 35-62, N-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LIN7B antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: B, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This LIN7B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 35-62 amino acids from the N-terminal region of human LIN7B.

Clone: RB40557

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-LIN7B antibody (ABIN1881500)

Zucker, Kama, Kuhn, Thu, Orlando, Dunah, Gokce, Taylor, Lambeck, Friedrich, Lindenberg, Faull, Weiller, Young, Luthi-Carter: "Decreased Lin7b expression in layer 5 pyramidal neurons may contribute to impaired corticostriatal connectivity in huntington disease." in: Journal of neuropathology and experimental neurology, Vol. 69, Issue 9, pp. 880-95, (2010) (PubMed).

Sudo, Ito, Iwamoto, Morishita, Asano, Nagata: "Identification of a cell polarity-related protein, Lin-7B, as a binding partner for a Rho effector, Rhotekin, and their possible interaction in neurons." in: Neuroscience research, Vol. 56, Issue 4, pp. 347-55, (2006) (PubMed).

Li, Benard, Margolskee: "Ggamma13 interacts with PDZ domain-containing proteins." in: The Journal of biological chemistry, Vol. 281, Issue 16, pp. 11066-73, (2006) (PubMed).

Kawai, Fukuda, Mukai, Murata: "MJ0917 in archaeon Methanococcus jannaschii is a novel NADP phosphatase/NAD kinase." in: The Journal of biological chemistry, Vol. 280, Issue 47, pp. 39200-7, (2005) (PubMed).

Target Details for LIN7B

Target: LIN7B (Lin-7 Homolog B (LIN7B))

Alternative Name: LIN7B (LIN7B Products)

Synonyms: LIN7B antibody, LIN-7B antibody, MALS-2 antibody, MALS2 antibody, VELI2 antibody, Veli2 antibody, Veli1a antibody, lin-7 homolog B, crumbs cell polarity complex component antibody, lin-7 homolog B (C. elegans) antibody, LIN7B antibody, Lin7b antibody

Background: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ACCN3 acid-evoked currents by stabilizing the channel at the cell surface (By similarity).

Molecular Weight: 22896

NCBI Accession: NP_071448

UniProt: Q9HAP6

Pathways: Synaptic Membrane