Keratin 86 antibody (AA 300-327)

Catalog No. ABIN1881488

Product Details anti-Keratin 86 Antibody

Target: Keratin 86 (KRT86)

Binding Specificity: AA 300-327

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Keratin 86 antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: Sh, B, M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This KRT86 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 300-327 amino acids from the Central region of human KRT86.

Clone: RB42669

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-Keratin 86 antibody (ABIN1881488)

ZHANG, MENG, ZHAO, TIAN: "Mutation E402K of the hHb6 in a Chinese Han family with monilethrix." in: European journal of dermatology : EJD, Vol. 19, Issue 5, pp. 508-9, (2009) (PubMed).

Feng, Liu, Yang: "[Analysis of human hair basic keratin 6 gene mutation in a Chinese Han family with monilethrix]." in: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, Vol. 25, Issue 2, pp. 141-4, (2008) (PubMed).

Lamesch, Li, Milstein, Fan, Hao, Szabo, Hu, Venkatesan, Bethel, Martin, Rogers, Lawlor, McLaren, Dricot, Borick, Cusick, Vandenhaute, Dunham, Hill, Vidal: "hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes." in: Genomics, Vol. 89, Issue 3, pp. 307-15, (2007) (PubMed).

Schweizer, Bowden, Coulombe, Langbein, Lane, Magin, Maltais, Omary, Parry, Rogers, Wright: "New consensus nomenclature for mammalian keratins." in: The Journal of cell biology, Vol. 174, Issue 2, pp. 169-74, (2006) (PubMed).

Target Details for Keratin 86

Target: Keratin 86 (KRT86)

Alternative Name: KRT86 (KRT86 Products)

Synonyms: Kb26 antibody, KRT86 antibody, HB6 antibody, Hb1 antibody, KRTHB1 antibody, KRTHB6 antibody, MNX antibody, hHb6 antibody, 5430421N21Rik antibody, AI325212 antibody, Khb4 antibody, Krt2-10 antibody, Krt2-11 antibody, MHb4 antibody, keratin 86 antibody, hair keratin type II intermediate filament antibody, Krt86 antibody, KRT86 antibody, KRT2.11 antibody

Background: The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle, this hair keratin, as well as KRTHB1 and KRTHB3, is found primarily in the hair cortex. Mutations in this gene and KRTHB1 have been observed in patients with a rare dominant hair disease, monilethrix.

Molecular Weight: 53501

NCBI Accession: NP_002275

UniProt: O43790