KRT6A antibody (AA 212-240)

Catalog No. ABIN1881486

Product Details anti-KRT6A Antibody

Target: KRT6A (Keratin 6A (KRT6A))

Binding Specificity: AA 212-240

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KRT6A antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Mouse Krt6a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 212-240 amino acids from the Central region of mouse Krt6a.

Clone: RB40714

Isotype: IgG

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-KRT6A antibody (ABIN1881486)

Sehic, Khuu, Risnes, Osmundsen et al.: "Differential gene expression profiling of the molar tooth germ in peroxisome proliferator-activated receptor-alpha (PPAR-alpha) knockout mouse and in wild-type mouse: molar tooth phenotype of..." in: European journal of oral sciences, Vol. 117, Issue 2, pp. 93-104, (2009) (PubMed).

Chen, Jaeger, Den, Koch, Sundberg, Roop: "Mice expressing a mutant Krt75 (K6hf) allele develop hair and nail defects resembling pachyonychia congenita." in: The Journal of investigative dermatology, Vol. 128, Issue 2, pp. 270-9, (2008) (PubMed).

Cui, Kunisada, Esibizione, Grivennikov, Piao, Nedospasov, Schlessinger: "Lymphotoxin-beta regulates periderm differentiation during embryonic skin development." in: Human molecular genetics, Vol. 16, Issue 21, pp. 2583-90, (2007) (PubMed).

Gu, Coulombe: "Keratin expression provides novel insight into the morphogenesis and function of the companion layer in hair follicles." in: The Journal of investigative dermatology, Vol. 127, Issue 5, pp. 1061-73, (2007) (PubMed).

Kurek, Garinis, van Doorninck, van der Wees, Grosveld: "Transcriptome and phenotypic analysis reveals Gata3-dependent signalling pathways in murine hair follicles." in: Development (Cambridge, England), Vol. 134, Issue 2, pp. 261-72, (2006) (PubMed).

Target Details for KRT6A

Target: KRT6A (Keratin 6A (KRT6A))

Alternative Name: Krt6a (KRT6A Products)

Synonyms: CK6A antibody, CK6C antibody, CK6D antibody, K6A antibody, K6C antibody, K6D antibody, KRT6C antibody, KRT6D antibody, 2310016L08Rik antibody, Krt2-6a antibody, Krt2-6c antibody, MK6a antibody, mK6[a] antibody, CK-6A antibody, Krt6a antibody, KRT6A antibody, keratin 6A antibody, similar to keratin complex 2, basic, gene 6a antibody, keratin, type II cytoskeletal 6A antibody, KRT6A antibody, Krt6a antibody, LOC683313 antibody, LOC101112304 antibody

Background: Keratins 6 and 16 are expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyperproliferation related keratins). Keratin 6 is found in hair follicles, neck squamous cell carcinomas, suprabasal cells of a variety of internal stratified epithelia, in epidermis, in both normal and hyperproliferative situations. Epidermal injury results in activation of keratinocytes which express CK6 and CK16. CK6 is strongly expressed in about 75 % of head and neck squamous cell carcinomas. Expression of CK6 is particularly associated with differentiation. There are at least six isoforms of human type II keratin 6 (K6), K6A being the most abundant representing about 77 % of all forms found in epithelia.

Molecular Weight: 59335

NCBI Accession: NP_032502

UniProt: P50446