ICT1 antibody (C-Term)

Catalog No. ABIN1881444

Product Details anti-ICT1 Antibody

Target: ICT1 (Immature Colon Carcinoma Transcript 1 (ICT1))

Binding Specificity: AA 153-179, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ICT1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ICT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 153-179 amino acids from the C-terminal region of human ICT1.

Clone: RB42881

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:25. IHC-P: 1:25

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-ICT1 antibody (ABIN1881444)

Wang, He, Zhang, Yang, Wang, Liu, Wu: "Knockdown of Immature Colon Carcinoma Transcript 1 Inhibits Proliferation and Promotes Apoptosis of Non-Small Cell Lung Cancer Cells." in: Technology in cancer research & treatment, Vol. 16, Issue 5, pp. 559-569, (2018) (PubMed).

Tao, Song, Han, Wang, Zhao, Gu: "miR-205 regulation of ICT1 has an oncogenic potential via promoting the migration and invasion of gastric cancer cells." in: Biomedicine & pharmacotherapy, Vol. 96, pp. 191-197, (2018) (PubMed).

Wang, Jin, Wu, Wang, Li: "Immature colon carcinoma transcript-1 promotes proliferation of gastric cancer cells." in: Acta biochimica et biophysica Sinica, Vol. 49, Issue 11, pp. 979-988, (2018) (PubMed).

Chang, Yu, Tian, Lin: "Immature colon carcinoma transcript-1 promotes cell growth of hepatocellular carcinoma via facilitating cell cycle progression and apoptosis resistance." in: Oncology reports, Vol. 38, Issue 6, pp. 3489-3496, (2018) (PubMed).

Xie, Zhang, Shen, Cao, Gu, Che: "Knockdown of immature colon carcinoma transcript-1 inhibits proliferation of glioblastoma multiforme cells through Gap 2/mitotic phase arrest." in: OncoTargets and therapy, Vol. 8, pp. 1119-27, (2015) (PubMed).

Target Details for ICT1

Target: ICT1 (Immature Colon Carcinoma Transcript 1 (ICT1))

Alternative Name: ICT1 (ICT1 Products)

Synonyms: ICT1 antibody, DS-1 antibody, DS1 antibody, 1110001A02Rik antibody, 1110002E03Rik antibody, mitochondrial ribosomal protein L58 antibody, imitochondrial ribosomal protein L58 S homeolog antibody, Immature colon carcinoma transcript 1 antibody, MRPL58 antibody, mrpl58.S antibody, PVX_091510 antibody, mrpl58 antibody, Mrpl58 antibody, ict1 antibody

Background: Essential peptidyl-tRNA hydrolase component of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation. May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes.

Molecular Weight: 23630

NCBI Accession: NP_001536

UniProt: Q14197