GUCA1C antibody (C-Term)

Catalog No. ABIN1881400

Product Details anti-GUCA1C Antibody

Target: GUCA1C (Guanylate Cyclase Activator 1C (GUCA1C))

Binding Specificity: AA 171-199, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GUCA1C antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This GUCA1C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 171-199 amino acids from the C-terminal region of human GUCA1C.

Clone: RB42656

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-GUCA1C antibody (ABIN1881400)

Stephen, Palczewski, Sousa: "The crystal structure of GCAP3 suggests molecular mechanism of GCAP-linked cone dystrophies." in: Journal of molecular biology, Vol. 359, Issue 2, pp. 266-75, (2006) (PubMed).

Imanishi, Li, Sokal, Sowa, Lichtarge, Wensel, Saperstein, Baehr, Palczewski: "Characterization of retinal guanylate cyclase-activating protein 3 (GCAP3) from zebrafish to man." in: The European journal of neuroscience, Vol. 15, Issue 1, pp. 63-78, (2002) (PubMed).

Haeseleer, Sokal, Li, Pettenati, Rao, Bronson, Wechter, Baehr, Palczewski: "Molecular characterization of a third member of the guanylyl cyclase-activating protein subfamily." in: The Journal of biological chemistry, Vol. 274, Issue 10, pp. 6526-35, (1999) (PubMed).

Target Details for GUCA1C

Target: GUCA1C (Guanylate Cyclase Activator 1C (GUCA1C))

Alternative Name: GUCA1C (GUCA1C Products)

Synonyms: gcap3 antibody, GCAP3 antibody, guanylate cyclase activator 1C antibody, guca1c antibody, GUCA1C antibody

Background: GUCA1C stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low and inhibits guanylyl cyclases when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of guanylyl cyclase (GC) is a key event in recovery of the dark state of rod photoreceptors following light exposure.

Molecular Weight: 23822

NCBI Accession: NP_005450

UniProt: O95843

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction