GTPBP3 antibody (AA 293-320)

Catalog No. ABIN1881398

Product Details anti-GTPBP3 Antibody

Target: GTPBP3 (GTP Binding Protein 3 (Mitochondrial) (GTPBP3))

Binding Specificity: AA 293-320

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GTPBP3 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This GTPBP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 293-320 amino acids from the Central region of human GTPBP3.

Clone: RB40710

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-GTPBP3 antibody (ABIN1881398)

Reiling, van Vliet-Ostaptchouk, van t Riet, van Haeften, Arp, Hansen, Kremer, Groenewoud, van Hove, Romijn, Smit, Nijpels, Heine, Uitterlinden, Pedersen, Slagboom, Maassen, Hofker, t Hart, Dekker: "Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study." in: European journal of human genetics : EJHG, Vol. 17, Issue 8, pp. 1056-62, (2009) (PubMed).

Villarroya, Prado, Esteve, Soriano, Aguado, Pérez-Martínez, Martínez-Ferrandis, Yim, Victor, Cebolla, Montaner, Knecht, Armengod: "Characterization of human GTPBP3, a GTP-binding protein involved in mitochondrial tRNA modification." in: Molecular and cellular biology, Vol. 28, Issue 24, pp. 7514-31, (2008) (PubMed).

Bykhovskaya, Mengesha, Wang, Yang, Estivill, Shohat, Fischel-Ghodsian: "Phenotype of non-syndromic deafness associated with the mitochondrial A1555G mutation is modulated by mitochondrial RNA modifying enzymes MTO1 and GTPBP3." in: Molecular genetics and metabolism, Vol. 83, Issue 3, pp. 199-206, (2004) (PubMed).

Li, Guan: "Identification and characterization of mouse GTPBP3 gene encoding a mitochondrial GTP-binding protein involved in tRNA modification." in: Biochemical and biophysical research communications, Vol. 312, Issue 3, pp. 747-54, (2003) (PubMed).

Li, Guan: "A human mitochondrial GTP binding protein related to tRNA modification may modulate phenotypic expression of the deafness-associated mitochondrial 12S rRNA mutation." in: Molecular and cellular biology, Vol. 22, Issue 21, pp. 7701-11, (2002) (PubMed).

Target Details for GTPBP3

Target: GTPBP3 (GTP Binding Protein 3 (Mitochondrial) (GTPBP3))

Alternative Name: GTPBP3 (GTPBP3 Products)

Synonyms: GTPBP3 antibody, zgc:112394 antibody, 2410009F13Rik antibody, AI607903 antibody, GTPBG3 antibody, MSS1 antibody, MTGP1 antibody, THDF1 antibody, GTP binding protein 3, mitochondrial antibody, GTP binding protein 3 antibody, GTPBP3 antibody, Gtpbp3 antibody, gtpbp3 antibody

Background: This locus encodes a GTP-binding protein. The encoded protein is localized to the mitochondria and may play a role in mitochondrial tRNA modification. Polymorphisms at this locus may be associated with severity of aminoglycoside-induced deafness, a disease associated with a mutation in the 12S rRNA. Alternatively spliced transcript variants encoding different isoforms have been described.

Molecular Weight: 52058

NCBI Accession: NP_001122327, NP_001182351, NP_116009, NP_598399

UniProt: Q969Y2