GAR1 antibody (AA 86-114)

Catalog No. ABIN1881363

Product Details anti-GAR1 Antibody

Target: GAR1 (GAR1 Ribonucleoprotein Homolog (Yeast) (GAR1))

Binding Specificity: AA 86-114

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GAR1 antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: Zf, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This GAR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86-114 amino acids from the Central region of human GAR1.

Clone: RB39831

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-GAR1 antibody (ABIN1881363)

Hamma, Ferré-DAmaré: "The box H/ACA ribonucleoprotein complex: interplay of RNA and protein structures in post-transcriptional RNA modification." in: The Journal of biological chemistry, Vol. 285, Issue 2, pp. 805-9, (2010) (PubMed).

Kalsi, Kuo, Aliev, Alexander, McMichael, Patterson, Walsh, Zhao, Schuckit, Nurnberger, Edenberg, Kramer, Hesselbrock, Tischfield, Vladimirov, Prescott, Dick, Kendler, Riley: "A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts." in: Human molecular genetics, Vol. 19, Issue 12, pp. 2497-506, (2010) (PubMed).

Pigullo, Pavesi, Dianzani, Santamaria, Svahn, Risso, Van Lint, Pillon, Iori, Longoni, Ramenghi, Lanciotti, Dufour: "NOLA1 gene mutations in acquired aplastic anemia." in: Pediatric blood & cancer, Vol. 52, Issue 3, pp. 376-8, (2009) (PubMed).

Target Details for GAR1

Target: GAR1 (GAR1 Ribonucleoprotein Homolog (Yeast) (GAR1))

Alternative Name: GAR1 (GAR1 Products)

Synonyms: 46.t00052 antibody, Tb04.5D20.620 antibody, NOLA1 antibody, Nola1 antibody, AA409823 antibody, AI326794 antibody, C430047J18Rik antibody, nola1 antibody, zgc:56086 antibody, GAR1 homolog, ribonucleoprotein antibody, snoRNP protein gar1 antibody, snoRNP protein GAR1 antibody, GAR1 ribonucleoprotein antibody, gar1 antibody, EHI_194040 antibody, Tc00.1047053510687.120 antibody, Tb927.4.470 antibody, PVX_122305 antibody, Bm1_39105 antibody, CMU_040070 antibody, LOAG_03932 antibody, GAR1 antibody, Gar1 antibody

Background: This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA2 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. These four H/ACA snoRNP proteins are also components of the telomerase complex. The encoded protein of this gene contains two glycine- and arginine-rich domains and is related to Saccharomyces cerevisiae Gar1p. Two splice variants have been found for this gene.

Molecular Weight: 22348

NCBI Accession: NP_061856, NP_127460

UniProt: Q9NY12