FMO5 antibody (C-Term)

Catalog No. ABIN1881348

Product Details anti-FMO5 Antibody

Target: FMO5 (Flavin Containing Monooxygenase 5 (FMO5))

Binding Specificity: AA 474-502, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FMO5 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This FMO5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 474-502 amino acids from the C-terminal region of human FMO5.

Clone: RB42789

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-FMO5 antibody (ABIN1881348)

Ross, Katzov-Eckert, Dubé, Brooks, Rassekh, Barhdadi, Feroz-Zada, Visscher, Brown, Rieder, Rogers, Phillips, Carleton, Hayden: "Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy." in: Nature genetics, Vol. 41, Issue 12, pp. 1345-9, (2009) (PubMed).

Furnes, Feng, Sommer, Schlenk: "Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans." in: Drug metabolism and disposition: the biological fate of chemicals, Vol. 31, Issue 2, pp. 187-93, (2003) (PubMed).

Target Details for FMO5

Target: FMO5 (Flavin Containing Monooxygenase 5 (FMO5))

Alternative Name: FMO5 (FMO5 Products)

Synonyms: MGC68633 antibody, MGC108355 antibody, sb:cb1007 antibody, wu:fc05b01 antibody, wu:fk47g04 antibody, 5033418D19Rik antibody, AI195026 antibody, flavin containing monooxygenase 5 S homeolog antibody, flavin containing monooxygenase 5 antibody, fmo5.S antibody, fmo5 antibody, MCYG_00559 antibody, FMO5 antibody, Fmo5 antibody

Background: Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Alternative splicing results in multiple transcript variants.

Molecular Weight: 60221

NCBI Accession: NP_001138301, NP_001138302, NP_001452

UniProt: P49326