FCRL3 antibody (C-Term)

Catalog No. ABIN1881343

Product Details anti-FCRL3 Antibody

Target: FCRL3 (Fc Receptor-Like 3 (FCRL3))

Binding Specificity: AA 694-720, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FCRL3 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This FCRL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 694-720 amino acids from the C-terminal region of human FCRL3.

Clone: RB41960

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-FCRL3 antibody (ABIN1881343)

Swainson, Mold, Bajpai, McCune: "Expression of the autoimmune susceptibility gene FcRL3 on human regulatory T cells is associated with dysfunction and high levels of programmed cell death-1." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 184, Issue 7, pp. 3639-47, (2010) (PubMed).

Davila, Froeling, Tan, Bonnard, Boland, Snippe, Hibberd, Seielstad: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, (2010) (PubMed).

Zheng, Zhao, Zhang, Li: "[Study on the association of 3 SNPs of FcRL3 gene with Graves disease in Chongqing Han population]." in: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, Vol. 26, Issue 6, pp. 681-5, (2009) (PubMed).

Gibson, Li, Wu, Edberg, Su, Cafardi, Wiener, Tiwari, Kimberly, Davis: "The FCRL3-169CT promoter single-nucleotide polymorphism, which is associated with systemic lupus erythematosus in a Japanese population, predicts expression of receptor protein on CD19+ B cells." in: Arthritis and rheumatism, Vol. 60, Issue 11, pp. 3510-2, (2009) (PubMed).

Target Details for FCRL3

Target: FCRL3 (Fc Receptor-Like 3 (FCRL3))

Alternative Name: FCRL3 (FCRL3 Products)

Synonyms: CD307c antibody, FCRH3 antibody, IFGP3 antibody, IRTA3 antibody, SPAP2 antibody, fcrh3 antibody, ifgp3 antibody, irta3 antibody, spap2 antibody, xfl1.2 antibody, Fc receptor like 3 antibody, Fc receptor-like 3 L homeolog antibody, Fc receptor-like 3 antibody, Fc receptor-like 3 S homeolog antibody, FCRL3 antibody, fcrl3.L antibody, fcrl3 antibody, fcrl3.S antibody

Background: This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus.

Molecular Weight: 80856

NCBI Accession: NP_443171

UniProt: Q96P31