DCLK2 antibody (N-Term)

Catalog No. ABIN1881253

Product Details anti-DCLK2 Antibody

Target: DCLK2 (Doublecortin-Like Kinase 2 (DCLK2))

Binding Specificity: AA 167-196, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DCLK2 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This DCLK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 167-196 amino acids from the N-terminal region of human DCLK2.

Clone: RB41922

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-DCLK2 antibody (ABIN1881253)

Dijkmans, van Hooijdonk, Fitzsimons, Vreugdenhil: "The doublecortin gene family and disorders of neuronal structure." in: Central nervous system agents in medicinal chemistry, Vol. 10, Issue 1, pp. 32-46, (2010) (PubMed).

Kerjan, Koizumi, Han, Dubé, Djakovic, Patrick, Baram, Heinemann, Gleeson: "Mice lacking doublecortin and doublecortin-like kinase 2 display altered hippocampal neuronal maturation and spontaneous seizures." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 16, pp. 6766-71, (2009) (PubMed).

Gorelik, Sapir, Reiner: "Gene trapping: an antibody-dependent approach for verifying integration in your favorite gene." in: Cellular & molecular biology letters, Vol. 13, Issue 4, pp. 614-20, (2008) (PubMed).

Target Details for DCLK2

Target: DCLK2 (Doublecortin-Like Kinase 2 (DCLK2))

Alternative Name: DCLK2 (DCLK2 Products)

Synonyms: CL2 antibody, CLICK-II antibody, CLICK2 antibody, CLIK2 antibody, DCAMKL2 antibody, DCDC3 antibody, DCDC3B antibody, DCK2 antibody, 6330415M09Rik antibody, AU044875 antibody, Click-II antibody, Dcamkl2 antibody, DCLK2 antibody, cb572 antibody, dclk antibody, sb:cb572 antibody, si:dkey-180n16.1 antibody, Dck2 antibody, RGD1308384 antibody, doublecortin like kinase 2 antibody, doublecortin-like kinase 2 antibody, doublecortin-like kinase 2a antibody, DCLK2 antibody, Dclk2 antibody, dclk2a antibody

Background: This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified.

Molecular Weight: 83606

NCBI Accession: NP_001035350, NP_001035351

UniProt: Q8N568