CXCR4 antibody (N-Term)

Catalog No. ABIN1881244

Product Details anti-CXCR4 Antibody

Target: CXCR4 (Chemokine (C-X-C Motif) Receptor 4 (CXCR4))

Binding Specificity: AA 50-79, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CXCR4 antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: B, Pr, M, Pig, Rat, Sh

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CXCR4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 50-79 amino acids from the N-terminal region of human CXCR4.

Clone: RB41207

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-CXCR4 antibody (ABIN1881244)

Zhou, Liu, Li, Zhang, Wang, Lan, Shi, Li, Ju: "Migration ability and Toll-like receptor expression of human mesenchymal stem cells improves significantly after three-dimensional culture." in: Biochemical and biophysical research communications, Vol. 491, Issue 2, pp. 323-328, (2017) (PubMed).

Zhu, Hong, Tripathi, Sehdev, Belkhiri, El-Rifai: "Regulation of CXCR4-mediated invasion by DARPP-32 in gastric cancer cells." in: Molecular cancer research : MCR, Vol. 11, Issue 1, pp. 86-94, (2013) (PubMed).

Hammad, Kuang, Yan, Allen, Dupré: "Na+/H+ exchanger regulatory factor-1 is involved in chemokine receptor homodimer CCR5 internalization and signal transduction but does not affect CXCR4 homodimer or CXCR4-CCR5 heterodimer." in: The Journal of biological chemistry, Vol. 285, Issue 45, pp. 34653-64, (2010) (PubMed).

Wang, Guilpain, Chong, Chouzenoux, Guillevin, Du, Zhou, Lin, Fairhurst, Boudreaux, Roux, Wakeland, Davis, Batteux, Mohan: "Dysregulated expression of CXCR4/CXCL12 in subsets of patients with systemic lupus erythematosus." in: Arthritis and rheumatism, Vol. 62, Issue 11, pp. 3436-46, (2010) (PubMed).

Cheng, Zhou, Wu, Boriboun, Thorne, Liu, Xiang, Zeng, Tanaka, Tang, Kishore, Tomasson, Miller, Losordo, Qin: "CXCR4-mediated bone marrow progenitor cell maintenance and mobilization are modulated by c-kit activity." in: Circulation research, Vol. 107, Issue 9, pp. 1083-93, (2010) (PubMed).

Sanematsu, Hirashima, Laurin, Takii, Nishikimi, Kitajima, Ding, Noda, Murata, Tanaka, Masuko, Suda, Meno, C��té, Nagasawa, Fukui: "DOCK180 is a Rac activator that regulates cardiovascular development by acting downstream of CXCR4." in: Circulation research, Vol. 107, Issue 9, pp. 1102-5, (2010) (PubMed).

Target Details for CXCR4

Target: CXCR4 (Chemokine (C-X-C Motif) Receptor 4 (CXCR4))

Alternative Name: CXCR4 (CXCR4 Products)

Synonyms: CD184 antibody, D2S201E antibody, FB22 antibody, HM89 antibody, HSY3RR antibody, LAP3 antibody, LCR1 antibody, LESTR antibody, NPY3R antibody, NPYR antibody, NPYRL antibody, NPYY3R antibody, WHIM antibody, Cmkar4 antibody, PB-CKR antibody, PBSF/SDF-1 antibody, Sdf1r antibody, CXC-R4-B antibody, CXCR-4-B antibody, cd184 antibody, cxcr4 antibody, fb22 antibody, hm89 antibody, hsy3rr antibody, lap3 antibody, lcr1 antibody, lestr antibody, npy3r antibody, npyr antibody, npyrl antibody, npyy3r antibody, xcxcr4 antibody, CXC-R4 antibody, CXCR-4 antibody, d2s201e antibody, whim antibody, CXC-R4-A antibody, CXCR-4-A antibody, xCXCR4 antibody, CXCR4 antibody, cb403 antibody, zgc:109863 antibody, cb824 antibody, C-X-C motif chemokine receptor 4 antibody, chemokine (C-X-C motif) receptor 4 antibody, C-X-C motif chemokine receptor 4 S homeolog antibody, C-X-C chemokine receptor type 4 antibody, C-X-C motif chemokine receptor 4 L homeolog antibody, chemokine (C-X-C motif), receptor 4b antibody, chemokine (C-X-C motif) receptor 4a antibody, CXCR4 antibody, Cxcr4 antibody, cxcr4.S antibody, cxcr4 antibody, LOC100049444 antibody, cxcr4.L antibody, cxcr4b antibody, cxcr4a antibody

Background: This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq].

Molecular Weight: 39746

NCBI Accession: NP_001008540, NP_003458

UniProt: P61073

Pathways: Regulation of Cell Size, CXCR4-mediated Signaling Events