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CRYAA antibody (AA 77-106)

CRYAA Reactivity: Human WB Host: Rabbit Polyclonal RB28544 unconjugated
Catalog No. ABIN1881229
  • Target See all CRYAA Antibodies
    CRYAA (Crystallin, alpha A (CRYAA))
    Binding Specificity
    • 6
    • 5
    • 4
    • 1
    • 1
    • 1
    AA 77-106
    Reactivity
    • 45
    • 17
    • 16
    • 3
    • 1
    Human
    Host
    • 27
    • 18
    • 1
    Rabbit
    Clonality
    • 27
    • 19
    Polyclonal
    Conjugate
    • 20
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CRYAA antibody is un-conjugated
    Application
    • 34
    • 27
    • 17
    • 11
    • 6
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
    Predicted Reactivity
    B, Hs, M, Pig, Rb, Rat, Sh
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This CRYAA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 77-106 amino acids from the Central region of human CRYAA.
    Clone
    RB28544
    Isotype
    Ig Fraction
    Top Product
    Discover our top product CRYAA Primary Antibody
  • Application Notes
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Expiry Date
    6 months
  • Deng, Chen, Xie, Zhao, Gong, Liu, Zhang, Sun, Liu, Ma, Batra, Li: "The small heat shock protein alphaA-crystallin is expressed in pancreas and acts as a negative regulator of carcinogenesis." in: Biochimica et biophysica acta, Vol. 1802, Issue 7-8, pp. 621-31, (2010) (PubMed).

    Li, Yang, Ma, Zhang, Zhang, Wang, Zhu: "Autosomal dominant congenital nuclear cataracts caused by a CRYAA gene mutation." in: Current eye research, Vol. 35, Issue 6, pp. 492-8, (2010) (PubMed).

    Pang, Su, Feng, Tang, Gu, Zhang, Ma, Yan: "Effects of congenital cataract mutation R116H on alphaA-crystallin structure, function and stability." in: Biochimica et biophysica acta, Vol. 1804, Issue 4, pp. 948-56, (2010) (PubMed).

    Bhagyalaxmi, Padma, Reddy, Reddy: "Association of G>A transition in exon-1 of alpha crystallin gene in age-related cataracts." in: Oman journal of ophthalmology, Vol. 3, Issue 1, pp. 7-12, (2010) (PubMed).

  • Target
    CRYAA (Crystallin, alpha A (CRYAA))
    Alternative Name
    CRYAA (CRYAA Products)
    Synonyms
    CRYA1 antibody, CTRCT9 antibody, HSPB4 antibody, AI323437 antibody, Acry-1 antibody, Crya-1 antibody, Crya1 antibody, DAcry-1 antibody, lop18 antibody, alpha-a-crystallin antibody, cryaa-A antibody, CRYAA antibody, wu:fc06h04 antibody, zgc:92036 antibody, HspB4 antibody, crystallin alpha A antibody, crystallin, alpha A antibody, alphaA-crystallin antibody, alpha-crystallin A chain-like antibody, crystallin alpha A S homeolog antibody, alpha-crystallin A chain antibody, CRYAA antibody, Cryaa antibody, CpipJ_CPIJ005646 antibody, cryaa antibody, LOC100384978 antibody, cryaa.S antibody, LOC458589 antibody, LOC102724652 antibody
    Background
    Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families, beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone, instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits, the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed, alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Defects in this gene cause autosomal dominant congenital cataract (ADCC). [provided by RefSeq].
    Molecular Weight
    19909
    NCBI Accession
    NP_000385
    UniProt
    P02489
    Pathways
    M Phase
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