This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This CMIP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 735-764 amino acids from the C-terminal region of human CMIP.
CMIP
Reactivity: Human
WB, ELISA
Host: Rabbit
Polyclonal
unconjugated
Application Notes
WB: 1:1000
Restrictions
For Research Use only
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Expiry Date
6 months
Audard, Zhang, Copie-Bergman, Rucker-Martin, Ory, Candelier, Baia, Lang, Pawlak, Sahali: "Occurrence of minimal change nephrotic syndrome in classical Hodgkin lymphoma is closely related to the induction of c-mip in Hodgkin-Reed Sternberg cells and podocytes." in: Blood, Vol. 115, Issue 18, pp. 3756-62, (2010) (PubMed).
Kamal, Pawlak, BenMohamed, Valanciuté, Dahan, Candelier, Lang, Guellaën, Sahali: "C-mip interacts with the p85 subunit of PI3 kinase and exerts a dual effect on ERK signaling via the recruitment of Dip1 and DAP kinase." in: FEBS letters, Vol. 584, Issue 3, pp. 500-6, (2010) (PubMed).
Hanna, Kruskal, Ezekowitz, Bloom, Collier: "Role of macrophage oxidative burst in the action of anthrax lethal toxin." in: Molecular medicine (Cambridge, Mass.), Vol. 1, Issue 1, pp. 7-18, (1996) (PubMed).
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Background
CMIP plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor.