CLDN14 antibody (C-Term)

Catalog No. ABIN1881208

Product Details anti-CLDN14 Antibody

Target: CLDN14 (Claudin 14 (CLDN14))

Binding Specificity: AA 172-200, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CLDN14 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CLDN14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 172-200 amino acids from the C-terminal region of human CLDN14.

Clone: RB42184

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-CLDN14 antibody (ABIN1881208)

Thorleifsson, Holm, Edvardsson, Walters, Styrkarsdottir, Gudbjartsson, Sulem, Halldorsson, de Vegt, dAncona, den Heijer, Franzson, Christiansen, Alexandersen, Rafnar, Kristjansson: "Sequence variants in the CLDN14 gene associate with kidney stones and bone mineral density." in: Nature genetics, Vol. 41, Issue 8, pp. 926-30, (2009) (PubMed).

Belguith, Tlili, Dhouib, Ben Rebeh, Lahmar, Charfeddine, Driss, Ghorbel, Ayadi, Masmoudi: "Mutation in gap and tight junctions in patients with non-syndromic hearing loss." in: Biochemical and biophysical research communications, Vol. 385, Issue 1, pp. 1-5, (2009) (PubMed).

Hanna, Kruskal, Ezekowitz, Bloom, Collier: "Role of macrophage oxidative burst in the action of anthrax lethal toxin." in: Molecular medicine (Cambridge, Mass.), Vol. 1, Issue 1, pp. 7-18, (1996) (PubMed).

Target Details for CLDN14

Target: CLDN14 (Claudin 14 (CLDN14))

Alternative Name: CLDN14 (CLDN14 Products)

Synonyms: claudin-14 antibody, CLDN14 antibody, DFNB29 antibody, AI851731 antibody, claudin 14 L homeolog antibody, claudin 14 antibody, cldn14.L antibody, CLDN14 antibody, Cldn14 antibody

Background: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. The encoded protein also binds specifically to the WW domain of Yes-associated protein. Defects in this gene are the cause of an autosomal recessive form of nonsyndromic sensorineural deafness. It is also reported that four synonymous variants in this gene are associated with kidney stones and reduced bone mineral density. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq].

Molecular Weight: 25699

NCBI Accession: NP_001139549, NP_001139550, NP_001139551, NP_036262, NP_652763

UniProt: O95500

Pathways: Cell-Cell Junction Organization, Hepatitis C