CHN1 antibody (N-Term)

Catalog No. ABIN1881198

Product Details anti-CHN1 Antibody

Target: CHN1 (ARHGAP2) (rho GTPase Activating Protein 2 (ARHGAP2))

Binding Specificity: AA 1-30, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHN1 antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CHN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CHN1.

Clone: RB42774

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-CHN1 antibody (ABIN1881198)

Volk, Fricke, Strobl, Kolling, Kubisch, Neugebauer: "Analysis of the CHN1 gene in patients with various types of congenital ocular motility disorders." in: Graefe's archive for clinical and experimental ophthalmology, Vol. 248, Issue 9, pp. 1351-7, (2010) (PubMed).

Murillo-Correa, Kon-Jara, Engle, Zenteno: "Clinical features associated with an I126M alpha2-chimaerin mutation in a family with autosomal-dominant Duane retraction syndrome." in: Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus / American Association for Pediatric Ophthalmology and Strabismus, Vol. 13, Issue 3, pp. 245-8, (2009) (PubMed).

Hanna, Kruskal, Ezekowitz, Bloom, Collier: "Role of macrophage oxidative burst in the action of anthrax lethal toxin." in: Molecular medicine (Cambridge, Mass.), Vol. 1, Issue 1, pp. 7-18, (1996) (PubMed).

Target Details for CHN1

Target: CHN1 (ARHGAP2) (rho GTPase Activating Protein 2 (ARHGAP2))

Alternative Name: CHN1 (ARHGAP2 Products)

Background: This gene encodes GTPase-activating protein for p21-rac and a phorbol ester receptor. It plays an important role in ocular motor axon pathfinding. Heterozygous missense mutations in this gene cause Duane's retraction syndrome 2 (DURS2). Multiple transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 53172

NCBI Accession: NP_001020372, NP_001193531, NP_001813

UniProt: P15882