CDKN3 antibody (N-Term)

Catalog No. ABIN1881194

Product Details anti-CDKN3 Antibody

Target: CDKN3 (Cyclin-Dependent Kinase Inhibitor 3 (CDKN3))

Binding Specificity: AA 39-68, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDKN3 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CDKN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-68 amino acids from the N-terminal region of human CDKN3.

Clone: RB42328

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-CDKN3 antibody (ABIN1881194)

Jiang, Xia, Li, Deng, Zhao, Shi, Wang, Sun: "High expression levels of IKKalpha and IKKbeta are necessary for the malignant properties of liver cancer." in: International journal of cancer. Journal international du cancer, Vol. 126, Issue 5, pp. 1263-74, (2010) (PubMed).

Shimada, Miyagawa, Kawashima, Tanaka, Honda, Honda, Tokunaga: "An approach based on a genome-wide association study reveals candidate loci for narcolepsy." in: Human genetics, Vol. 128, Issue 4, pp. 433-41, (2010) (PubMed).

Okamoto, Kitabayashi, Taya: "KAP1 dictates p53 response induced by chemotherapeutic agents via Mdm2 interaction." in: Biochemical and biophysical research communications, Vol. 351, Issue 1, pp. 216-22, (2006) (PubMed).

Hsieh, Yao, Lai, Yang: "Transcriptional repression activity of PAX3 is modulated by competition between corepressor KAP1 and heterochromatin protein 1." in: Biochemical and biophysical research communications, Vol. 349, Issue 2, pp. 573-81, (2006) (PubMed).

Chinami, Yano, Yang, Salahuddin, Moriyama, Shiroishi, Turner, Shirakawa, Adra et al.: "Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated phosphatase (KAP).Cdk2.cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP..." in: The Journal of biological chemistry, Vol. 280, Issue 17, pp. 17235-42, (2005) (PubMed).

Target Details for CDKN3

Target: CDKN3 (Cyclin-Dependent Kinase Inhibitor 3 (CDKN3))

Alternative Name: CDKN3 (CDKN3 Products)

Synonyms: CDI1 antibody, CIP2 antibody, KAP antibody, KAP1 antibody, CDKN3 antibody, 2410006H10Rik antibody, K24G6.15 antibody, K24G6_15 antibody, KIP-RELATED PROTEIN 3 antibody, KRP3 antibody, inhibitor/interactor with cyclin-dependent kinase antibody, cyclin dependent kinase inhibitor 3 antibody, cyclin-dependent kinase inhibitor 3 antibody, inhibitor/interactor with cyclin-dependent kinase antibody, CDKN3 antibody, cdkn3 antibody, Cdkn3 antibody, ICK6 antibody

Background: The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 23805

NCBI Accession: NP_001124323, NP_005183

UniProt: Q16667