CDCA7L antibody (C-Term)

Catalog No. ABIN1881189

Product Details anti-CDCA7L Antibody

Target: CDCA7L (Cell Division Cycle Associated 7-Like (CDCA7L))

Binding Specificity: AA 290-317, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDCA7L antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CDCA7L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 290-317 amino acids from the C-terminal region of human CDCA7L.

Clone: RB43388

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-CDCA7L antibody (ABIN1881189)

Huang, Ho, Ponzielli, Barsyte-Lovejoy, Bouffet, Picard, Hawkins, Penn: "Identification of a novel c-Myc protein interactor, JPO2, with transforming activity in medulloblastoma cells." in: Cancer research, Vol. 65, Issue 13, pp. 5607-19, (2005) (PubMed).

Chen, Ou, Chen, Choi, Shih: "R1, a novel repressor of the human monoamine oxidase A." in: The Journal of biological chemistry, Vol. 280, Issue 12, pp. 11552-9, (2005) (PubMed).

Scherer, Cheung, MacDonald, Osborne, Nakabayashi, Herbrick, Carson, Parker-Katiraee, Skaug, Khaja, Zhang, Hudek, Li, Haddad, Duggan, Fernandez, Kanematsu, Gentles, Christopoulos, Choufani, Kwasnicka et al.: "Human chromosome 7: DNA sequence and biology. ..." in: Science (New York, N.Y.), Vol. 300, Issue 5620, pp. 767-72, (2003) (PubMed).

Target Details for CDCA7L

Target: CDCA7L (Cell Division Cycle Associated 7-Like (CDCA7L))

Alternative Name: CDCA7L (CDCA7L Products)

Synonyms: ram2 antibody, MGC154777 antibody, BC006933 antibody, JPO2 antibody, R1 antibody, RAM2 antibody, RAPGEF5 antibody, cell division cycle associated 7 like antibody, cell division cycle associated 7 like L homeolog antibody, cell division cycle-associated 7-like protein antibody, CDCA7L antibody, cdca7l.L antibody, LOC100454683 antibody, Cdca7l antibody

Background: Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways, May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.

UniProt: B3KTR5