Cyclin D1 antibody (C-Term)
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- Target See all Cyclin D1 (CCND1) Antibodies
- Cyclin D1 (CCND1)
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Binding Specificity
- AA 267-294, C-Term
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Cyclin D1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Purification
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- Immunogen
- This CCND1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 267-294 amino acids from the C-terminal region of human CCND1.
- Clone
- RB42158
- Isotype
- Ig Fraction
- Top Product
- Discover our top product CCND1 Primary Antibody
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- Application Notes
- WB: 1:1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Expiry Date
- 6 months
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TRAF4 enhances oral squamous cell carcinoma cell growth, invasion and migration by Wnt-β-catenin signaling pathway." in: International journal of clinical and experimental pathology, Vol. 8, Issue 9, pp. 11837-46, (2016) (PubMed).
: "Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase." in: Cancer cell, Vol. 18, Issue 4, pp. 329-40, (2010) (PubMed).
: "PIK3CA mutation uncouples tumor growth and cyclin D1 regulation from MEK/ERK and mutant KRAS signaling." in: Cancer research, Vol. 70, Issue 17, pp. 6804-14, (2010) (PubMed).
: "Preliminary comparison of tumor biologic factors in breast carcinomas from Australian and Chinese women." in: Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology, Vol. 32, Issue 3, pp. 155-60, (2010) (PubMed).
: "RNA interference-mediated URG4 gene silencing diminishes cyclin D1 mRNA expression in HepG2 cells." in: Genetics and molecular research : GMR, Vol. 9, Issue 3, pp. 1557-67, (2010) (PubMed).
: "Cyclin D1 blocks the anti-proliferative function of RUNX3 by interfering with RUNX3-p300 interaction." in: Biochemical and biophysical research communications, Vol. 400, Issue 3, pp. 426-31, (2010) (PubMed).
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TRAF4 enhances oral squamous cell carcinoma cell growth, invasion and migration by Wnt-β-catenin signaling pathway." in: International journal of clinical and experimental pathology, Vol. 8, Issue 9, pp. 11837-46, (2016) (PubMed).
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- Target
- Cyclin D1 (CCND1)
- Alternative Name
- CCND1 (CCND1 Products)
- Synonyms
- BCL1 antibody, D11S287E antibody, PRAD1 antibody, U21B31 antibody, AI327039 antibody, CycD1 antibody, Cyl-1 antibody, bcl-1 antibody, cD1 antibody, cb161 antibody, cycd1 antibody, etID37810.7 antibody, fb52e01 antibody, fc45c08 antibody, fc83a12 antibody, id:ibd1198 antibody, wu:fb52e01 antibody, wu:fc45c08 antibody, wu:fc83a12 antibody, ccnd1b antibody, prad1 antibody, ccnd1 antibody, ccnd1a antibody, bcl1 antibody, d11s287e antibody, u21b31 antibody, CCND1 antibody, cyclin D1 antibody, cyclin D1 S homeolog antibody, cyclin D1 L homeolog antibody, CCND1 antibody, Ccnd1 antibody, ccnd1 antibody, ccnd1.S antibody, ccnd1.L antibody
- Background
- The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
- Molecular Weight
- 33729
- NCBI Accession
- NP_444284
- UniProt
- P24385
- Pathways
- PI3K-Akt Signaling, Cell Division Cycle, Mitotic G1-G1/S Phases, ER-Nucleus Signaling
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