Cyclin B2 antibody (pSer22)

Catalog No. ABIN1881157

Product Details anti-Cyclin B2 Antibody

Target: Cyclin B2 (CCNB2)

Binding Specificity: pSer22

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cyclin B2 antibody is un-conjugated

Application: Dot Blot (DB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CCNB2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S22 of human CCNB2.

Clone: RB42147

Isotype: Ig Fraction

Application Details

Application Notes: DB: 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-Cyclin B2 antibody (ABIN1881157)

Haraguchi, Ishikawa, Yamaguchi, Fujisawa: "Cyclin and protamine as prognostic molecular marker for testicular sperm extraction in patients with azoospermia." in: Fertility and sterility, Vol. 91, Issue 4 Suppl, pp. 1424-6, (2009) (PubMed).

De Martino, Visone, Wierinckx, Palmieri, Ferraro, Cappabianca, Chiappetta, Forzati, Lombardi, Colao, Trouillas, Fedele, Fusco: "HMGA proteins up-regulate CCNB2 gene in mouse and human pituitary adenomas." in: Cancer research, Vol. 69, Issue 5, pp. 1844-50, (2009) (PubMed).

Cunningham, Vierkant, Sellers, Phelan, Rider, Liebow, Schildkraut, Berchuck, Couch, Wang, Fridley, Gentry-Maharaj, Menon, Hogdall, Kjaer, Whittemore, DiCioccio, Song, Gayther, Ramus, Pharaoh, Goode: "Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis." in: British journal of cancer, Vol. 101, Issue 8, pp. 1461-8, (2009) (PubMed).

Bellanger, de Gramont, Sobczak-Thépot: "Cyclin B2 suppresses mitotic failure and DNA re-replication in human somatic cells knocked down for both cyclins B1 and B2." in: Oncogene, Vol. 26, Issue 51, pp. 7175-84, (2007) (PubMed).

Stav, Bar, Sandbank: "Usefulness of CDK5RAP3, CCNB2, and RAGE genes for the diagnosis of lung adenocarcinoma." in: The International journal of biological markers, Vol. 22, Issue 2, pp. 108-13, (2007) (PubMed).

Target Details for Cyclin B2

Target: Cyclin B2 (CCNB2)

Alternative Name: CCNB2 (CCNB2 Products)

Synonyms: HsT17299 antibody, CycB2 antibody, sb:cb303 antibody, cycB2 antibody, LOC100136691 antibody, C-B2 antibody, cyclinb2 antibody, hst17299 antibody, LOC100282653 antibody, cyclin B2 antibody, cyclin B2 S homeolog antibody, CCNB2 antibody, Ccnb2 antibody, ccnb2 antibody, LOC100136691 antibody, LOC100282653 antibody, ccnb2.S antibody

Background: Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control.

Molecular Weight: 45282

NCBI Accession: NP_004692

UniProt: O95067

Pathways: Cell Division Cycle, M Phase