CNR1 antibody (AA 161-187)

Catalog No. ABIN1881140

Product Details anti-CNR1 Antibody

Target: CNR1 (Cannabinoid Receptor 1 (CNR1))

Binding Specificity: AA 161-187

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CNR1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 161-187 amino acids of human CB1.

Clone: RB41743

Isotype: IgG

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-CNR1 antibody (ABIN1881140)

Van Laere, Casteels, Dhollander, Goffin, Grachev, Bormans, Vandenberghe: "Widespread decrease of type 1 cannabinoid receptor availability in Huntington disease in vivo." in: Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Vol. 51, Issue 9, pp. 1413-7, (2010) (PubMed).

Monteleone, Milano, Petrella, Canestrelli, Maj: "Endocannabinoid Pro129Thr FAAH functional polymorphism but not 1359G/A CNR1 polymorphism is associated with antipsychotic-induced weight gain." in: Journal of clinical psychopharmacology, Vol. 30, Issue 4, pp. 441-5, (2010) (PubMed).

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, (2010) (PubMed).

Larrinaga, Varona, Pérez, Sanz, Ugalde, Cándenas, Pinto, Gil, López: "Expression of cannabinoid receptors in human kidney." in: Histology and histopathology, Vol. 25, Issue 9, pp. 1133-8, (2010) (PubMed).

Target Details for CNR1

Target: CNR1 (Cannabinoid Receptor 1 (CNR1))

Alternative Name: CB1 (CNR1 Products)

Synonyms: CANN6 antibody, CB-R antibody, CB1 antibody, CB1A antibody, CB1K5 antibody, CB1R antibody, CNR antibody, SKR6R antibody, cnr1-A antibody, cannabinoid receptor 1 antibody, cannabinoid receptor 1 (brain) antibody, cannabinoid receptor 1 (brain) S homeolog antibody, CNR1 antibody, Cnr1 antibody, cnr1 antibody, cnr1.S antibody

Background: This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq].

Molecular Weight: 52858

NCBI Accession: NP_001153698, NP_001153730, NP_001153731, NP_057167, NP_149421

UniProt: P21554

Pathways: Feeding Behaviour