BTRC antibody (N-Term)

Catalog No. ABIN1881122

Product Details anti-BTRC Antibody

Target: BTRC (beta-Transducin Repeat Containing (BTRC))

Binding Specificity: AA 127-156, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BTRC antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This BTRC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 127-156 amino acids from the N-terminal region of human BTRC.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-BTRC antibody (ABIN1881122)

Wan, Tang, Tytler, Lu, Jin, Vickers, Yang, Shi, Cao: "Smad4 protein stability is regulated by ubiquitin ligase SCF beta-TrCP1." in: The Journal of biological chemistry, Vol. 279, Issue 15, pp. 14484-7, (2004) (PubMed).

Zhou, Deng, Xia, Xu, Li, Gunduz, Hung: "Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition." in: Nature cell biology, Vol. 6, Issue 10, pp. 931-40, (2004) (PubMed).

Busino, Donzelli, Chiesa, Guardavaccaro, Ganoth, Dorrello, Hershko, Pagano, Draetta: "Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage." in: Nature, Vol. 426, Issue 6962, pp. 87-91, (2003) (PubMed).

Yaron, Hatzubai, Davis, Lavon, Amit, Manning, Andersen, Mann, Mercurio, Ben-Neriah: "Identification of the receptor component of the IkappaBalpha-ubiquitin ligase." in: Nature, Vol. 396, Issue 6711, pp. 590-4, (1999) (PubMed).

Margottin, Bour, Durand, Selig, Benichou, Richard, Thomas, Strebel, Benarous: "A novel human WD protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif." in: Molecular cell, Vol. 1, Issue 4, pp. 565-74, (1998) (PubMed).

Target Details for BTRC

Target: BTRC (beta-Transducin Repeat Containing (BTRC))

Alternative Name: BTRC (BTRC Products)

Synonyms: BTRC antibody, Beta-TrCP antibody, betaTrCP antibody, btrcp antibody, btrcp1 antibody, fbw1a antibody, fbxw1 antibody, fbxw1a antibody, fwd1 antibody, btrc antibody, beta-TrCP antibody, BETA-TRCP antibody, FBW1A antibody, FBXW1 antibody, FBXW1A antibody, FWD1 antibody, bTrCP antibody, bTrCP1 antibody, beta-TrCP1 antibody, btrc-a antibody, Beta-Trcp1 antibody, Fbw1a antibody, HOS antibody, Slimb antibody, b-TrCP antibody, mKIAA4123 antibody, beta-transducin repeat containing E3 ubiquitin protein ligase antibody, beta-transducin repeat containing antibody, beta-TrCP antibody, beta-transducin repeat containing E3 ubiquitin protein ligase S homeolog antibody, beta-transducin repeat containing protein antibody, BTRC antibody, btrc antibody, LOC100634006 antibody, Btrc antibody, btrc.S antibody

Background: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE, the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22'. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, SMAD3, SMAD4, CDC25A, DLG1, FBXO5 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of phosphorylated SNAI1. May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3.

Molecular Weight: 68867

NCBI Accession: NP_003930, NP_378663

UniProt: Q9Y297

Pathways: Cell Division Cycle, Hedgehog Signaling