BAT1 antibody (C-Term)

Catalog No. ABIN1881102

Product Details anti-BAT1 Antibody

Target: BAT1 (DDX39) (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 39 (DDX39))

Binding Specificity: AA 351-380, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BAT1 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Predicted Reactivity: M, Rat, B, C, D, Pig

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This BAT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 351-380 amino acids from the C-terminal region of human BAT1.

Clone: RB22515

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-BAT1 antibody (ABIN1881102)

Choudhary, Kumar, Gnad, Nielsen, Rehman, Walther, Olsen, Mann: "Lysine acetylation targets protein complexes and co-regulates major cellular functions." in: Science (New York, N.Y.), Vol. 325, Issue 5942, pp. 834-40, (2009) (PubMed).

Target Details for BAT1

Target: BAT1 (DDX39) (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 39 (DDX39))

Alternative Name: BAT1 (DDX39 Products)

Synonyms: dxd39 antibody, MGC53693 antibody, MGC130793 antibody, ddx39 antibody, MGC53944 antibody, DDX39 antibody, 2610307C23Rik antibody, BAT1 antibody, DDXL antibody, Ddx39a antibody, URH49 antibody, bat1 antibody, uap56 antibody, D6S81E antibody, UAP56 antibody, Bat1 antibody, Bat1a antibody, p47 antibody, DEAD-box helicase 39A S homeolog antibody, nuclear RNA helicase antibody, DExD-box helicase 39A antibody, DEAD-box helicase 39A antibody, ATP-dependent RNA helicase DDX39 antibody, ATP-dependent RNA helicase DDX39A antibody, DEAD (Asp-Glu-Ala-Asp) box polypeptide 39b antibody, DEAD (Asp-Glu-Ala-Asp) box polypeptide 39 antibody, DEAD-box helicase 39B L homeolog antibody, DExD-box helicase 39B antibody, ddx39a.S antibody, ddx39 antibody, DDX39A antibody, ddx39a antibody, LOC100084960 antibody, ddx39b antibody, Ddx39 antibody, ddx39b.L antibody, DDX39B antibody, Ddx39b antibody

Background: Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing-and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between THOC4 and the cap-binding protein NCBP1. UAP56 functions as a bridge between THOC4 and the THO complex. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and THOC4. Splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint. It has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity. Even with the stimulation of RNA, the ATPase activity is weak. It can only hydrolyze ATP but not other NTPs. The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA. However, ssRNA stimulates the ATPase activity much more strongly than dsRNA. It can unwind 5' or 3' overhangs or blunt end RNA duplexes in vitro. The ATPase and helicase activities are not influenced by U2AF2 and THOC4.

Molecular Weight: 48991

NCBI Accession: NP_004631, NP_542165

UniProt: Q13838

Pathways: Ribonucleoprotein Complex Subunit Organization