ASCL1 antibody (N-Term)

Catalog No. ABIN1881074

Product Details anti-ASCL1 Antibody

Target: ASCL1 (Achaete-Scute Complex Homolog 1 (Drosophila) (ASCL1))

Binding Specificity: AA 63-90, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ASCL1 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ASCL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-90 amino acids from the N-terminal region of human ASCL1.

Clone: RB41522

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-ASCL1 antibody (ABIN1881074)

Phi, Kim, Eun, Wang, Park, Choi, Kim, Park, Cho, Kim: "Upregulation of SOX2, NOTCH1, and ID1 in supratentorial primitive neuroectodermal tumors: a distinct differentiation pattern from that of medulloblastomas." in: Journal of neurosurgery. Pediatrics, Vol. 5, Issue 6, pp. 608-14, (2010) (PubMed).

McGaughey, McCallion: "Efficient discovery of ASCL1 regulatory sequences through transgene pooling." in: Genomics, Vol. 95, Issue 6, pp. 363-9, (2010) (PubMed).

Li, Zhong, Li, Huang, Wang, Zheng, Zhang: "[Expression and clinicopathologic significance of human achaete-scute homolog 1 in pulmonary neuroendocrine tumors]." in: Zhongguo fei ai za zhi = Chinese journal of lung cancer, Vol. 13, Issue 4, pp. 317-21, (2010) (PubMed).

Deng, Yang, Le, Deng, Xu, Xiong, Zhu, Xie, Song, Jankovic: "Examination of the MASH1 gene in patients with Parkinson's disease." in: Biochemical and biophysical research communications, Vol. 392, Issue 4, pp. 548-50, (2010) (PubMed).

Improgo, Schlichting, Cortes, Zhao-Shea, Tapper, Gardner: "ASCL1 regulates the expression of the CHRNA5/A3/B4 lung cancer susceptibility locus." in: Molecular cancer research : MCR, Vol. 8, Issue 2, pp. 194-203, (2010) (PubMed).

Target Details for ASCL1

Target: ASCL1 (Achaete-Scute Complex Homolog 1 (Drosophila) (ASCL1))

Alternative Name: ASCL1 (ASCL1 Products)

Synonyms: ASH1 antibody, HASH1 antibody, MASH1 antibody, bHLHa46 antibody, AI225900 antibody, Mash1 antibody, ASCL1 antibody, Zash-1a antibody, ash antibody, asha antibody, id:ibd5085 antibody, im:7138587 antibody, si:dkey-264k15.2 antibody, zash1a antibody, zasha antibody, Xash1 antibody, ascl1-A antibody, Zash-1b antibody, ashb antibody, zashb antibody, achaete-scute family bHLH transcription factor 1 antibody, achaete-scute family bHLH transcription factor 1a antibody, achaete-scute family bHLH transcription factor 1 L homeolog antibody, achaete-scute complex homolog 1 antibody, achaete-scute family bHLH transcription factor 1b antibody, ASCL1 antibody, Ascl1 antibody, ascl1a antibody, ascl1.L antibody, LOC100220505 antibody, ascl1b antibody

Background: This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases.

Molecular Weight: 25454

NCBI Accession: NP_004307

UniProt: P50553

Pathways: Dopaminergic Neurogenesis