Angiomotin antibody (pTyr599)

Catalog No. ABIN1881054

Product Details anti-Angiomotin Antibody

Target: Angiomotin (AMOT)

Binding Specificity: pTyr599

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Angiomotin antibody is un-conjugated

Application: Dot Blot (DB)

Predicted Reactivity: M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This AMOT Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y599 of human AMOT.

Clone: RB41443

Isotype: Ig Fraction

Application Details

Application Notes: DB: 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-Angiomotin antibody (ABIN1881054)

Heller, Adu-Gyamfi, Smith-Kinnaman, Babbey, Vora, Xue, Bittman, Stahelin, Wells: "Amot recognizes a juxtanuclear endocytic recycling compartment via a novel lipid binding domain." in: The Journal of biological chemistry, Vol. 285, Issue 16, pp. 12308-20, (2010) (PubMed).

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, (2010) (PubMed).

Gagné, Moreau, Plourde, Lapointe, Lord, Gagnon, Fernandes: "Human angiomotin-like 1 associates with an angiomotin protein complex through its coiled-coil domain and induces the remodeling of the actin cytoskeleton." in: Cell motility and the cytoskeleton, Vol. 66, Issue 9, pp. 754-68, (2009) (PubMed).

Zheng, Vertuani, Nyström, Audebert, Meijer, Tegnebratt, Borg, Uhlén, Majumdar, Holmgren: "Angiomotin-like protein 1 controls endothelial polarity and junction stability during sprouting angiogenesis." in: Circulation research, Vol. 105, Issue 3, pp. 260-70, (2009) (PubMed).

Talmud, Drenos, Shah, Shah, Palmen, Verzilli, Gaunt, Pallas, Lovering, Li, Casas, Sofat, Kumari, Rodriguez, Johnson, Newhouse, Dominiczak, Samani, Caulfield, Sever, Stanton, Shields, Padmanabhan et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, (2009) (PubMed).

Target Details for Angiomotin

Target: Angiomotin (AMOT)

Alternative Name: AMOT (AMOT Products)

Synonyms: C81439 antibody, CAG-2 antibody, D0Kist1 antibody, E230009N18Rik antibody, Sii6 antibody, mKIAA1071 antibody, RGD1564027 antibody, si:dkey-13f9.6 antibody, wu:fj21a07 antibody, angiomotin antibody, microRNA 4329 antibody, AMOT antibody, Amot antibody, MIR4329 antibody, amot antibody

Background: This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms.

Molecular Weight: 118085

NCBI Accession: NP_001106962, NP_573572

UniProt: Q4VCS5

Pathways: Cell-Cell Junction Organization, Regulation of Cell Size