ADRA1B antibody (C-Term)

Catalog No. ABIN1881048

Product Details anti-ADRA1B Antibody

Target: ADRA1B (Adrenergic, alpha-1B-, Receptor (ADRA1B))

Binding Specificity: AA 380-409, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADRA1B antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: M, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ADRA1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 380-409 amino acids from the C-terminal region of human ADRA1B.

Clone: RB41818

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-ADRA1B antibody (ABIN1881048)

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, (2010) (PubMed).

Jensen, Swigart, De Marco, Hoopes, Simpson: "{alpha}1-Adrenergic receptor subtypes in nonfailing and failing human myocardium." in: Circulation. Heart failure, Vol. 2, Issue 6, pp. 654-63, (2009) (PubMed).

Talmud, Drenos, Shah, Shah, Palmen, Verzilli, Gaunt, Pallas, Lovering, Li, Casas, Sofat, Kumari, Rodriguez, Johnson, Newhouse, Dominiczak, Samani, Caulfield, Sever, Stanton, Shields, Padmanabhan et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, (2009) (PubMed).

Hanna, Kruskal, Ezekowitz, Bloom, Collier: "Role of macrophage oxidative burst in the action of anthrax lethal toxin." in: Molecular medicine (Cambridge, Mass.), Vol. 1, Issue 1, pp. 7-18, (1996) (PubMed).

Target Details for ADRA1B

Target: ADRA1B (Adrenergic, alpha-1B-, Receptor (ADRA1B))

Alternative Name: ADRA1B (ADRA1B Products)

Synonyms: LOC100136712 antibody, [a]1b antibody, ADRA1 antibody, ALPHA1BAR antibody, RDC5 antibody, alpha-1B adrenoceptor antibody, adrenoceptor alpha 1B antibody, adrenergic receptor, alpha 1b antibody, LOC100136712 antibody, ADRA1B antibody, Adra1b antibody

Background: Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region.

Molecular Weight: 56836

NCBI Accession: NP_000670

UniProt: P35368

Pathways: AMPK Signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process