SOCS5 antibody (N-Term)

Catalog No. ABIN184868

Product Details anti-SOCS5 Antibody

Target: SOCS5 (Suppressor of Cytokine Signaling 5 (SOCS5))

Binding Specificity: N-Term

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This SOCS5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purpose: SOCS5

Sequence: DKVGKMWNNF K

Specificity: Both reported variants represent identical protein: NP_054730.1 and NP_659198.1.

Cross-Reactivity: Cow, Human, Mouse, Pig, Rat

Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Grade: Verified

Immunogen: Peptide with sequence DKVGKMWNNFK-C, from the N Terminus of the protein sequence according to NP_054730.1.

Isotype: IgG

Application Details

Application Notes:

Western Blot: Approx 65 kDa band observed in lysates of cell line Molt4 (calculated MW of 61.2 kDa according to NP_054730.1). Recommended concentration: 0.3-1 μg/mL.

Peptide ELISA: antibody detection limit dilution 1:64000.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied at 0.5 mg/mL in Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Minimize freezing and thawing.

Storage: -20 °C

Storage Comment: Aliquot and store at -20°C, with minimal freeze/thawing. A working aliquot may be refrigerated at 4°C for a few weeks and still remain viable.

References for anti-SOCS5 antibody (ABIN184868)

Kuhad, Bishnoi, Tiwari, Chopra: "Suppression of NF-kappabeta signaling pathway by tocotrienol can prevent diabetes associated cognitive deficits." in: Pharmacology, biochemistry, and behavior, Vol. 92, Issue 2, pp. 251-9, (2009) (PubMed).

Target Details for SOCS5

Target: SOCS5 (Suppressor of Cytokine Signaling 5 (SOCS5))

Alternative Name: SOCS5 (SOCS5 Products)

Background: SOCS5, suppressor of cytokine signaling 5, CIS6, CISH6, KIAA0671, cytokine-inducible SH2 protein 6, Cish5, SOCS-5

Gene ID: 9655, 56468

NCBI Accession: NP_054730

Pathways: JAK-STAT Signaling, EGFR Signaling Pathway, Positive Regulation of Immune Effector Process