WHSC2 antibody (AA 280-511)

Catalog No. ABIN1846367

Product Details anti-WHSC2 Antibody

Target: WHSC2 (Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2))

Binding Specificity: AA 280-511

Reactivity: Human, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This WHSC2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (fixed cells) (IF/ICC)

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human WHSC2 (AA: 280-511) expressed in E. coli.

Isotype: IgG2b

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: PBS with 0.05 % sodium azide and 0.5 % protein stabilizer.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.

Target Details for WHSC2

Target: WHSC2 (Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2))

Alternative Name: WHSC2 (WHSC2 Products)

Synonyms: BcDNA:SD07139 antibody, CG5874 antibody, Dmel\\CG5874 antibody, NELF antibody, NELF-A antibody, Whsc2 antibody, fi75f03 antibody, whsc2 antibody, wu:fi75f03 antibody, MGC85474 antibody, WHSC2 antibody, nelfa antibody, nelf-a antibody, p/okcl.15 antibody, Whsc2h antibody, Negative elongation factor A antibody, negative elongation factor complex member A antibody, negative elongation factor complex member A L homeolog antibody, negative elongation factor complex member A, Whsc2 antibody, Nelf-A antibody, Nelfa antibody, nelfa antibody, nelfa.L antibody, NELFA antibody

Background: This gene is expressed ubiquitously with higher levels in fetal than in adult tissues.It encodes a protein sharing 93% sequence identity with the mouse protein.Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4.This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome.The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients.This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.

Molecular Weight: 57.3 kDa

Gene ID: 7469

Pathways: Chromatin Binding