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ROCK1 antibody
ROCK1
Reactivity: Human
WB, ELISA
Host: Mouse
Monoclonal
unconjugated
Product Details anti-ROCK1 Antibody
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Target
See all ROCK1 Antibodies
ROCK1
(rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1))
Reactivity
All reactivities for ROCK1 antibodies
Human
Host
All hosts for ROCK1 antibodies
Mouse
Clonality
All clonalities for ROCK1 antibodies
Monoclonal
Conjugate
All conjugates for ROCK1 antibodies
This ROCK1 antibody is un-conjugated
Application
All applications for ROCK1 antibodies
Western Blotting (WB), ELISA
Purification
Purified antibody
Immunogen
Purified recombinant fragment of human ROCK1 expressed in E. Coli.
Isotype
IgG1
Top Product
Discover our top product ROCK1 Primary Antibody
Alternatives
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anti-rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1) (pSer456), (pThr455) antibody
ROCK1
Reactivity: Human, Mouse, Rat
WB, ELISA, IF (cc), IF (p), FACS, IHC (p), IHC (fro)
Host: Rabbit
Polyclonal
unconjugated
Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1.0 mg/mL
Buffer
PBS with 0.05 % sodium azide and 0.5 % protein stabilizer.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
Target Details for ROCK1
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Target
ROCK1
(rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1))
Alternative Name
ROCK1 (ROCK1 Products )
Synonyms
LOC100229794 antibody, CG9774 antibody, DROK antibody, DRhk antibody, DRok antibody, Dmel\\CG9774 antibody, Drok antibody, ROCK antibody, ROCK-1 antibody, ROCK1 antibody, ROK antibody, ROKalpha/beta antibody, Rhk antibody, RhoK antibody, Rock antibody, Rok antibody, dROK antibody, dRok antibody, drok antibody, 1110055K06Rik antibody, Rock-I antibody, P160Rock antibody, ROCK-I antibody, P160ROCK antibody, p160ROCK antibody, Rho associated coiled-coil containing protein kinase 1 antibody, Rho kinase antibody, Rho-associated coiled-coil containing protein kinase 1 antibody, Rho-associated, coiled-coil containing protein kinase 1 antibody, ROCK1 antibody, Rok antibody, Rock1 antibody, rock1 antibody
Background
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.
Molecular Weight
158 kDa
Gene ID
6093
UniProt
Q13464
Pathways
Microtubule Dynamics , WNT Signaling , M Phase , Maintenance of Protein Location , Signaling Events mediated by VEGFR1 and VEGFR2 , Thromboxane A2 Receptor Signaling
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