KEAP1 antibody (AA 380-624)

Catalog No. ABIN1846111

Product Details anti-KEAP1 Antibody

Target: KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

Binding Specificity: AA 380-624

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This KEAP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human KEAP1 (AA: 380-624) expressed in E. coli.

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: PBS with 0.05 % sodium azide and 0.5 % protein stabilizer.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.

Target Details for KEAP1

Target: KEAP1 (Kelch-Like ECH-Associated Protein 1 (KEAP1))

Alternative Name: KEAP1 (KEAP1 Products)

Background: This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain.Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus.This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase.Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.

Molecular Weight: 69.7 kDa

Gene ID: 9817

UniProt: Q14145

Pathways: Maintenance of Protein Location