FcRn
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
Application Notes
Flow cytometry: 1.2 μg/10^6 cells br>ELISA: 1:200 - 1:400 br>CELISA: 1:200 - 1:400 br>For each application a titration should be performed to determine the optimal concentration.
Restrictions
For Research Use only
Buffer
PBS pH 7.2 with 50% glycerol
Handling Advice
avoid repeated freezing and thawing
Storage
4 °C
Xu, He, Momben-Abolfath, Vertrees, Li, Norton, Struble: "Zika Virus Infection and Antibody Neutralization in FcRn Expressing Placenta and Engineered Cell Lines." in: Vaccines, Vol. 10, Issue 12, (2022) (PubMed).
Christianson, Sun, Akilesh, Pesavento, Proetzel, Roopenian: "Monoclonal antibodies directed against human FcRn and their applications." in: mAbs, Vol. 4, Issue 2, pp. 208-16, (2014) (PubMed).
FCRN antibody, alpha-chain antibody, FcRn antibody, Fc fragment of IgG receptor and transporter antibody, Fc receptor, IgG, alpha chain transporter antibody, FCGRT antibody, Fcgrt antibody
Background
The MHC class I-like Fc receptor (FcRn) is an intracellular trafficking Fc receptor that is uniquely responsible for the extended serum half-life of antibodies of the IgG subclass and their ability to transport across cellular barriers. By performing these functions, FcRn affects numerous facets of antibody biology and pathobiology. Its critical role in controlling IgG pharmacokinetics has been leveraged for the design of therapeutic antibodies and related biologics. FcRn also traffics serum albumin and is responsible for the enhanced pharmacokinetic properties of albumin-conjugated therapeutics. Synonyms: IgG receptor FcRn large subunit p51, Neonatal Fc receptor, FCGRT