FcRn antibody
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- Key Features
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- High-quality FcRn antibody (Clone DVN24) for the detection of FcRn.
- Highly specific for human FcRn, blocks the binding of IgG.
- 2 PubMed references available for this FcRn antibody.
- Target See all FcRn Antibodies
- FcRn (IgG receptor FcRn (FcRn))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This FcRn antibody is un-conjugated
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Application
- ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Cell-ELISA (cELISA)
- Characteristics
- based on recognition of the complete native protein expressed on transfected mammalian cells
- Purification
- Purified, Protein G
- Immunogen
- hFcRn
- Clone
- DVN24
- Isotype
- IgG2a kappa
- Top Product
- Discover our top product FcRn Primary Antibody
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- Application Notes
- Flow cytometry: 1.2 μg/10^6 cells br>ELISA: 1:200 - 1:400 br>CELISA: 1:200 - 1:400 br>For each application a titration should be performed to determine the optimal concentration.
- Restrictions
- For Research Use only
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- Buffer
- PBS pH 7.2
- Handling Advice
- avoid repeated freezing and thawing
- Storage
- 4 °C
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- Target
- FcRn (IgG receptor FcRn (FcRn))
- Abstract
- FcRn Products
- Synonyms
- FCRN antibody, alpha-chain antibody, FcRn antibody, Fc fragment of IgG receptor and transporter antibody, Fc receptor, IgG, alpha chain transporter antibody, FCGRT antibody, Fcgrt antibody
- Background
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The MHC class I-like Fc receptor (FcRn) is an intracellular trafficking Fc receptor that is uniquely responsible for the extended serum half-life of antibodies of the IgG subclass and their ability to transport across cellular barriers. By performing these functions, FcRn affects numerous facets of antibody biology and pathobiology. Its critical role in controlling IgG pharmacokinetics has been leveraged for the design of therapeutic antibodies and related biologics. FcRn also traffics serum albumin and is responsible for the enhanced pharmacokinetic properties of albumin-conjugated therapeutics.
Synonyms: IgG receptor FcRn large subunit p51, Neonatal Fc receptor, FCGRT - UniProt
- P55899
- Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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