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SNAP25 antibody (AA 192-206)

SNAP25 Reactivity: Human, Rat, Mouse, Chicken, Zebrafish (Danio rerio), Hamster, Goldfish WB, ELISA, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1742235
  • Target See all SNAP25 Antibodies
    SNAP25 (Synaptosomal-Associated Protein, 25kDa (SNAP25))
    Binding Specificity
    • 17
    • 15
    • 8
    • 8
    • 7
    • 7
    • 6
    • 6
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 192-206
    Reactivity
    • 100
    • 69
    • 67
    • 9
    • 9
    • 9
    • 8
    • 8
    • 7
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Rat, Mouse, Chicken, Zebrafish (Danio rerio), Hamster, Goldfish
    Host
    • 99
    • 22
    • 4
    • 4
    • 1
    Rabbit
    Clonality
    • 100
    • 27
    • 1
    Polyclonal
    Conjugate
    • 70
    • 8
    • 6
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SNAP25 antibody is un-conjugated
    Application
    • 91
    • 47
    • 28
    • 17
    • 13
    • 13
    • 13
    • 12
    • 11
    • 11
    • 8
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC)
    Specificity
    Specific for SNAP 25.
    Purification
    antiserum
    Immunogen
    Synthetic peptide IDEANQRATKMLGSG (aa 192-206 in human SNAP 25) coupled to key-hole limpet hemocyanin via an added N-terminal cysteine residue.
    Top Product
    Discover our top product SNAP25 Primary Antibody
  • Application Notes
    WB: 1 : 10000 (AP staining)
    ICC: 1 : 100
    Comment

    Recognizes the Botulinum neurotoxin A cleavage product with reduced affinity. Does not detect the neurotoxin E cleavage product. Recognizes splice variants SNAP 25A and B. ELISA: Suitable as detector antibody for sandwich-ELISA as capture antibody (protocol for sandwich-ELISA).

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS
    Handling Advice
    Crude antisera are more robust than monoclonals. With anti-microbials added, they may be stored at 4 °C.
    Serum does not contain active proteases, in fact, serum itself contains a powerful cocktail of protease inhibitors. Frozen storage (-20 °C),however, is preferable.
    Storage
    4 °C/-20 °C
    Storage Comment
    Unlabeled antibodies are stable in this form without loss of quality at ambient temperatures for several weeks or even months. They can be stored at 4 °C for several years.
  • Schafer, Heller, Gunner, Heller, Gordon, Hammond, Wolf, Jung, Stevens: "Microglia contribute to circuit defects in Mecp2 null mice independent of microglia-specific loss of Mecp2 expression." in: eLife, Vol. 5, (2016) (PubMed).

    Fossati, Morini, Corradini, Antonucci, Trepte, Edry, Sharma, Papale, Pozzi, Defilippi, Meier, Brambilla, Turco, Rosenblum, Wanker, Ziv, Menna, Matteoli: "Reduced SNAP-25 increases PSD-95 mobility and impairs spine morphogenesis." in: Cell death and differentiation, Vol. 22, Issue 9, pp. 1425-36, (2015) (PubMed).

    Walter, Kurps, de Wit, Schöning, Toft-Bertelsen, Lauks, Ziomkiewicz, Weiss, Schulz, Fischer von Mollard, Verhage, Sørensen: "The SNARE protein vti1a functions in dense-core vesicle biogenesis." in: The EMBO journal, Vol. 33, Issue 15, pp. 1681-97, (2014) (PubMed).

    Wilhelm, Mandad, Truckenbrodt, Kröhnert, Schäfer, Rammner, Koo, Claßen, Krauss, Haucke, Urlaub, Rizzoli: "Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins." in: Science (New York, N.Y.), Vol. 344, Issue 6187, pp. 1023-8, (2014) (PubMed).

    Kung, Gong, Adedoyin, Ng, Bhargava, Ohara, Jasmin: "Evidence for glutamate as a neuroglial transmitter within sensory ganglia." in: PLoS ONE, Vol. 8, Issue 7, pp. e68312, (2013) (PubMed).

    Young, Franciosi, Spreeuw, Deng, Sanders, Tam, Huang, Singaraja, Zhang, Bissada, Kay, Hayden: "Low levels of human HIP14 are sufficient to rescue neuropathological, behavioural, and enzymatic defects due to loss of murine HIP14 in Hip14-/- mice." in: PLoS ONE, Vol. 7, Issue 5, pp. e36315, (2012) (PubMed).

    Vasileva, Horstmann, Geumann, Gitler, Kuner: "Synapsin-dependent reserve pool of synaptic vesicles supports replenishment of the readily releasable pool under intense synaptic transmission." in: The European journal of neuroscience, Vol. 36, Issue 8, pp. 3005-20, (2012) (PubMed).

    Camoletto, Vara, Morando, Connell, Marletto, Giustetto, Sassoè-Pognetto, Van Veldhoven, Ledesma: "Synaptic vesicle docking: sphingosine regulates syntaxin1 interaction with Munc18." in: PLoS ONE, Vol. 4, Issue 4, pp. e5310, (2009) (PubMed).

    Johansson, Ericsson, Janson, Beraki, Stanić, Mandic, Wikström, Hökfelt, Ogren, Rozell, Berggren, Bark: "An ancient duplication of exon 5 in the Snap25 gene is required for complex neuronal development/function." in: PLoS genetics, Vol. 4, Issue 11, pp. e1000278, (2008) (PubMed).

  • Target
    SNAP25 (Synaptosomal-Associated Protein, 25kDa (SNAP25))
    Alternative Name
    SNAP 25 (SNAP25 Products)
    Synonyms
    RIC-4 antibody, RIC4 antibody, SEC9 antibody, SNAP antibody, SNAP-25 antibody, bA416N4.2 antibody, dJ1068F16.2 antibody, SNAP-25B antibody, SNAP-25a antibody, ric-4 antibody, ric4 antibody, sec9 antibody, snap-25 antibody, Bdr antibody, sp antibody, fj55h11 antibody, snap25 antibody, wu:fj55h11 antibody, Snap antibody, snap25.2 antibody, wu:fj33h05 antibody, synaptosome associated protein 25 antibody, synaptosome associated protein 25kDa S homeolog antibody, synaptosomal-associated protein, 25kDa antibody, synaptosomal-associated protein 25 antibody, synaptosome associated protein 25kDa antibody, synaptosome associated protein 25kDa L homeolog antibody, zgc:101731 antibody, synaptosomal-associated protein, 25b antibody, SNAP25 antibody, Snap25 antibody, snap25.S antibody, snap25 antibody, BACOIKO003_07 antibody, Tsp_10811 antibody, snap25.L antibody, zgc:101731 antibody, snap25b antibody
    Pathways
    Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport
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