QKI antibody (AA 1-341)

Catalog No. ABIN1741377

Product Details anti-QKI Antibody

Target: QKI (Protein Quaking (QKI))

Binding Specificity: AA 1-341

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This QKI antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity: Detects ~36-38 kDa.

Cross-Reactivity: Human, Mouse, Rat

Purification: Protein G Purified

Immunogen: Fusion protein amino acids 1-341 (full-length) of human QKI-5. Mouse: 100% identity (341/341 amino acids identical). Rat: 99% identity (339/341 amino acids identical) >90% identity with QKI-6, QKI-7 and QKI-7b.

Clone: S147-6

Isotype: IgG2b

Application Details

Application Notes:

• WB (1:1000)
• optimal dilutions for assays should be determined by the user.

Comment:

1 μg/ml of ABIN1741377 was sufficient for detection of Pan-QKI in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.1 % sodium azide, Storage buffer may change when conjugated

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C

Target Details for QKI

Target: QKI (Protein Quaking (QKI))

Alternative Name: QKI (QKI Products)

Synonyms: Hqk antibody, QK antibody, QK1 antibody, QK3 antibody, hqkI antibody, 1110003F05Rik antibody, 1500005P18 antibody, QkI antibody, l(17)-1Wis antibody, l17Wis1 antibody, Qki antibody, CQKI antibody, QKI-5 antibody, PqkI antibody, BqkI antibody, qk antibody, qk1 antibody, quaking antibody, Xqua antibody, qki antibody, EQKI antibody, EqkI antibody, QKI, KH domain containing RNA binding antibody, quaking antibody, QKI, KH domain containing, RNA binding S homeolog antibody, QKI, KH domain containing, RNA binding L homeolog antibody, QKI antibody, Qk antibody, qki.S antibody, qki.L antibody, Qki antibody

Background: QKI is also called Protein Quaking or HqkI. QKI is an RNA-binding protein that plays a central role in myelinization. QKI acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation, and is itself, regulated by alternative splicing. QKI is expressed in the frontal cortex of brain, but is shown to be down-regulated in the brain of schizophrenic patients.

Gene ID: 9444

UniProt: Q96PU8