Amyloid Fibrils antibody
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- Target
- Amyloid Fibrils
- Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- Un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Dot Blot (DB)
- Specificity
- Reacts withepitopes common to many human amyloid fibrils and fibrillar oligomers but not prefibrillar oligomers or natively folded proteins. Predicted to recognize mouse and rat based on sequence homology.
- Purification
- Purified
- Immunogen
- Fibrils prepared from human Abeta42 peptide
- Isotype
- IgG
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- Application Notes
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Working dilution: Optimal dilutions should be determined by the end user.
The following are guidelines only:
WB1 -2 μg/mL DB0.5 - 1 μg/mL IHC1 -5 μg/mL ELISA1 - 10 μg/mL with amyloid fibril-containing samples on the solid phase. - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.5 mg/mL
- Buffer
- PBS pH 7.0, 50 % glycerol
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Dilute in PBS or medium which is identical to that used in the assay system.
- Storage
- -20 °C
- Storage Comment
- This product is stable for at least 1 year at -20°C. Freeze in multiple aliquots to avoid repeated freeze-thaw cycles.
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- Target
- Amyloid Fibrils
- Background
- Amyloid monomeric proteins can oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to be related to the accumulation of misfolded proteins as amyloid fibers.
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