Syndecan 1 antibody (AA 28-171)

Catalog No. ABIN1724936

Product Details anti-Syndecan 1 Antibody

Target: Syndecan 1 (SDC1)

Binding Specificity: AA 28-171

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Syndecan 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Purpose: SDC1 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human SDC1 (AA: 28-171) expressed in E. Coli.

Clone: 1A3H4

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-Syndecan 1 antibody (ABIN1724936)

Nunez, Siegal, Reddy, Wei: "CD138 (syndecan-1) expression in bone-forming tumors." in: American journal of clinical pathology, Vol. 137, Issue 3, pp. 423-8, (2012) (PubMed).

Karasneh, Ali, Shukla: "An important role for syndecan-1 in herpes simplex virus type-1 induced cell-to-cell fusion and virus spread." in: PLoS ONE, Vol. 6, Issue 9, pp. e25252, (2011) (PubMed).

Target Details for Syndecan 1

Target: Syndecan 1 (SDC1)

Alternative Name: SDC1 (SDC1 Products)

Background:

Description: The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein.

Aliases: SDC, CD138, SYND1, syndecan

Molecular Weight: 32.5kDa

Gene ID: 6382

HGNC: 6382

UniProt: P18827

Pathways: Glycosaminoglycan Metabolic Process, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Lipid Metabolism