NRF2 antibody (AA 356-589)

Catalog No. ABIN1724931

Product Details anti-NRF2 Antibody

Target: NRF2 (NFE2L2) (Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2))

Binding Specificity: AA 356-589

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NRF2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Purpose: NFE2L2 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human NFE2L2 (AA: 356-589) expressed in E. Coli.

Clone: 1A6G6

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-NRF2 antibody (ABIN1724931)

Sandford, Malhotra, Boezen, Siedlinski, Postma, Wong, Akhabir, He, Connett, Anthonisen, Paré, Biswal: "NFE2L2 pathway polymorphisms and lung function decline in chronic obstructive pulmonary disease." in: Physiological genomics, Vol. 44, Issue 15, pp. 754-63, (2012) (PubMed).

Target Details for NRF2

Target: NRF2 (NFE2L2) (Nuclear Factor (erythroid-Derived 2)-Like 2 (NFE2L2))

Alternative Name: NFE2L2 (NFE2L2 Products)

Synonyms: Nrf2 antibody, nfe2l2 antibody, wu:fc15g09 antibody, wu:fj67e03 antibody, NF-E2R2 antibody, NRF2 antibody, AI194320 antibody, nuclear factor, erythroid 2-like 2a antibody, nuclear factor, erythroid 2 like 2 S homeolog antibody, nuclear factor, erythroid 2 like 2 antibody, nuclear factor, erythroid derived 2, like 2 antibody, nuclear factor, erythroid 2-like 2 antibody, nfe2l2a antibody, nfe2l2.S antibody, NFE2L2 antibody, Nfe2l2 antibody

Background:

Description: This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters, many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been found for this gene.

Aliases: NRF2

Molecular Weight: 67.8kDa

Gene ID: 4780

HGNC: 4780

UniProt: Q16236

Pathways: ER-Nucleus Signaling, Negative Regulation of intrinsic apoptotic Signaling