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beta-2 Microglobulin antibody (AA 21-100)

Name: beta-2 Microglobulin antibody (AA 21-100)
Brand: antibodies-online
SKU: ABIN1724930
Price: 511.5 USD
Availability: InStock

B2M Reactivity: Human WB, FACS, ELISA, IHC Host: Mouse Monoclonal 3G5H8 unconjugated

Western blot analysis using B2M mouse mAb against Hela (1), HEK293 (2), HepG2 (3),RAJI (4), A431 (5) and Jurkat (6) cell lysate. (beta-2 Microglobulin antibody (AA 21-100))

Black line: Control Antigen (100 ng), Purple line: Antigen(10 ng), Blue line: Antigen (50 ng), Red line: Antigen (100 ng), (beta-2 Microglobulin antibody (AA 21-100))

ELISA

Flow cytometric analysis of A431 cells using B2M mouse mAb (green) and negative control (red). (beta-2 Microglobulin antibody (AA 21-100))

FACS

Western blot analysis using B2M mAb against human B2M (AA: 21-100) recombinant protein. (beta-2 Microglobulin antibody (AA 21-100))

Western blot analysis using B2M mAb against HEK293 (1) and B2M (AA: 21-100)-hIgGFc transfected HEK293 (2) cell lysate. (beta-2 Microglobulin antibody (AA 21-100))

Immunohistochemical analysis of paraffin-embedded ovarian cancer tissues using B2M mouse mAb with DAB staining. (beta-2 Microglobulin antibody (AA 21-100))

IHC

Immunohistochemical analysis of paraffin-embedded esophageal cancer tissues using B2M mouse mAb with DAB staining. (beta-2 Microglobulin antibody (AA 21-100))

IHC

7 images

(2 references)

Catalog No. ABIN1724930

Datasheet as PDF

Target See all beta-2 Microglobulin (B2M) Antibodies

beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))
Binding Specificity
19

17

15

5

5

5

5

3

2

2

1

1

1

1

1

1
AA 21-100
Reactivity
205

51

30

27

10

4

4

4

3

2

2

1

1

1

1
Human
Host
123

111

9

6

2

1
Mouse
Compatible Secondaries
Clonality
126

125

1
Monoclonal
Conjugate
111

32

25

13

13

7

3

3

3

3

3

3

3

3

3

3

3

3

3

1

1

1

1

1

1

1

1

1

1

1

1
This beta-2 Microglobulin antibody is un-conjugated
Application
127

106

75

66

59

41

40

31

26

18

17

15

13

12

6

4

3

3

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1
Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunohistochemistry (IHC)

Purpose

B2M Antibody

Purification

Purified antibody

Immunogen

Purified recombinant fragment of human B2M (AA: 21-100) expressed in E. Coli.

Clone

3G5H8

Isotype

IgG2a

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anti-beta-2-Microglobulin (B2M) antibody (Biotin)
B2M Reactivity: Human WB, FACS, ELISA, IP, IHC (p), ICC Host: Mouse Monoclonal B2M-01 Biotin

anti-beta-2-Microglobulin (B2M) antibody
B2M Reactivity: Human, Non-Human Primate FACS, IF, IHC (p) Host: Mouse Monoclonal B2M-961 unconjugated

Application Notes

ELISA: 1/10000
FCM: 1/200 - 1/400

Restrictions

For Research Use only
Format

Liquid

Buffer

Purified antibody in PBS with 0.05 % sodium azide.

Preservative

Sodium azide

Precaution of Use

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage

4 °C,-20 °C

Storage Comment

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Bernal, Ruiz-Cabello, Concha, Paschen, Garrido: "Implication of the ?2-microglobulin gene in the generation of tumor escape phenotypes." in: Cancer immunology, immunotherapy : CII, Vol. 61, Issue 9, pp. 1359-71, (2012) (PubMed).

Hermansen, Hummelshøj, Lundsgaard, Hornum, Keller, Fleckner, Fox, Poulsen, Jacobsen: "Increased serum ?2-microglobulin is associated with clinical and immunological markers of disease activity in systemic lupus erythematosus patients." in: Lupus, Vol. 21, Issue 10, pp. 1098-104, (2012) (PubMed).
Target

beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))

Alternative Name

B2M (B2M Products)

Synonyms

Ly-m11 antibody, beta2-m antibody, beta2m antibody, bwm antibody, wu:fa94c05 antibody, wu:fb10a09 antibody, b2m-W01 antibody, b2m-W03 antibody, b2m-Z01 antibody, b2m-Z02 antibody, b2m-Z03 antibody, B2M antibody, b2m antibody, B2MG antibody, wu:fb66f11 antibody, wu:fj01f08 antibody, zgc:64161 antibody, b-2-m antibody, beta-2-microglobulin antibody, beta-2 microglobulin antibody, beta-2-microglobulin S homeolog antibody, beta-2-microglobulin, like antibody, B2M antibody, B2m antibody, b2m antibody, b2m.S antibody, b2ml antibody

Background

This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.

Molecular Weight

13.7kDa

Gene ID

567

HGNC

567

UniProt

P61769

Pathways

TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process