IGFBP7 antibody (AA 52-156)

Catalog No. ABIN1724903

Product Details anti-IGFBP7 Antibody

Target: IGFBP7 (Insulin-Like Growth Factor Binding Protein 7 (IGFBP7))

Binding Specificity: AA 52-156

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IGFBP7 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Purpose: IGFBP7 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human IGFBP7 (AA: 52-156) expressed in E. Coli.

Clone: 1D9E7

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-IGFBP7 antibody (ABIN1724903)

Evdokimova, Tognon, Benatar, Yang, Krutikov, Pollak, Sorensen, Seth: "IGFBP7 binds to the IGF-1 receptor and blocks its activation by insulin-like growth factors." in: Science signaling, Vol. 5, Issue 255, pp. ra92, (2012) (PubMed).

Target Details for IGFBP7

Target: IGFBP7 (Insulin-Like Growth Factor Binding Protein 7 (IGFBP7))

Alternative Name: IGFBP7 (IGFBP7 Products)

Synonyms: zgc:85888 antibody, AGM antibody, FSTL2 antibody, IBP-7 antibody, IGFBP-7 antibody, IGFBP-7v antibody, IGFBPRP1 antibody, MAC25 antibody, PSF antibody, RAMSVPS antibody, TAF antibody, Fstl2 antibody, Mac25 antibody, insulin like growth factor binding protein 7 antibody, insulin-like growth factor binding protein 7 antibody, IGFBP7 antibody, igfbp7 antibody, Igfbp7 antibody

Background:

Description: This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307).

Aliases: AGM, PSF, TAF, FSTL2, IBP-7, MAC25, IGFBP-7, RAMSVPS, IGFBP-7v, IGFBPRP1

Molecular Weight: 29.1kDa

Gene ID: 3490

HGNC: 3490

UniProt: Q16270

Pathways: Growth Factor Binding