DIS3L2 antibody (AA 27-250)

Catalog No. ABIN1724900

Product Details anti-DIS3L2 Antibody

Target: DIS3L2 (DIS3-Like Exonuclease 2 (DIS3L2))

Binding Specificity: AA 27-250

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This DIS3L2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Purpose: DIS3L2 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human DIS3L2 (AA: 27-250) expressed in E. Coli.

Clone: 6C7B2

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-DIS3L2 antibody (ABIN1724900)

Du Toit: "Cytoskeleton: Formins induce nuclear actin assembly." in: Nature reviews. Molecular cell biology, Vol. 14, Issue 6, pp. 328, (2013) (PubMed).

Astuti, Morris, Cooper, Staals, Wake, Fews, Gill, Gentle, Shuib, Ricketts, Cole, van Essen, van Lingen, Neri, Opitz, Rump, Stolte-Dijkstra, Müller, Pruijn, Latif, Maher: "Germline mutations in DIS3L2 cause the Perlman syndrome of overgrowth and Wilms tumor susceptibility." in: Nature genetics, Vol. 44, Issue 3, pp. 277-84, (2012) (PubMed).

Target Details for DIS3L2

Target: DIS3L2 (DIS3-Like Exonuclease 2 (DIS3L2))

Alternative Name: DIS3L2 (DIS3L2 Products)

Synonyms: RGD1560168 antibody, DIS3L2 antibody, DKFZp469O0522 antibody, FAM6A antibody, PRLMNS antibody, hDIS3L2 antibody, 4930429A22Rik antibody, 8030493P09Rik antibody, DIS3-like 3'-5' exoribonuclease 2 antibody, DIS3 like 3'-5' exoribonuclease 2 antibody, DIS3-like exonuclease 2 antibody, Dis3l2 antibody, DIS3L2 antibody, LOC100344728 antibody

Background:

Description: The protein encoded by this gene is similar in sequence to 3'/5' exonucleolytic subunits of the RNA exosome. The exosome is a large multimeric ribonucleotide complex responsible for degrading various RNA substrates. Several transcript variants, some protein-coding and some not, have been found for this gene.

Aliases: FAM6A, PRLMNS

Molecular Weight: 99.3kDa

Gene ID: 129563

HGNC: 129563

UniProt: Q8IYB7

Pathways: Stem Cell Maintenance