Transferrin Receptor antibody (AA 608-727)

Catalog No. ABIN1724899

Product Details anti-Transferrin Receptor Antibody

Target: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Binding Specificity: AA 608-727

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Transferrin Receptor antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purpose: TFRC Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human TFRC (AA: 608-727) expressed in E. Coli.

Clone: 1A1B2

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-Transferrin Receptor antibody (ABIN1724899)

Płoszyńska, Ruckemann-Dziurdzińska, Jóźwik, Mikosik, Lisowska, Balcerska, Witkowski: "Cytometric evaluation of transferrin receptor 1 (CD71) in childhood acute lymphoblastic leukemia." in: Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society, Vol. 50, Issue 2, pp. 304-11, (2012) (PubMed).

Jian, Yang, Huang: "Src regulates Tyr(20) phosphorylation of transferrin receptor-1 and potentiates breast cancer cell survival." in: The Journal of biological chemistry, Vol. 286, Issue 41, pp. 35708-15, (2011) (PubMed).

Target Details for Transferrin Receptor

Target: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Alternative Name: TFRC (TFRC Products)

Synonyms: Trfr antibody, LOC100219280 antibody, tfr antibody, cd71 antibody, tfr1 antibody, trfr antibody, CD71 antibody, T9 antibody, TFR antibody, TFR1 antibody, TR antibody, TRFR antibody, p90 antibody, 2610028K12Rik antibody, AI195355 antibody, AI426448 antibody, AU015758 antibody, E430033M20Rik antibody, Mtvr-1 antibody, Mtvr1 antibody, transferrin receptor antibody, TFRC antibody, Tfrc antibody, tfrc antibody

Background:

Description: Transferrin receptor is a carrier protein for transferrin. It is needed for the import of iron into the cell and is regulated in response to intracellular iron concentration. Low iron concentrations promote increased levels of transferrin receptor, to increase iron intake into the cell. Thus, transferrin receptor maintains cellular iron homeostasis. Expression of human TFR1, but not human TFR2, in hamster cell lines markedly enhanced the infection of viruses pseudotyped with the glycoprotein of Machupo, Guanarito, and Junin viruses, but not with those of Lassa or lymphocytic choriomeningitis viruses. An anti-TFR1 antibody efficiently inhibited the replication of Machupo, Guanarito, Junin, and Sabia viruses, but not that of Lassa virus.TFR1 is a cellular receptor for New World hemorrhagic fever arenaviruses.

Aliases: T9, TR, TFR, p90, CD71, TFR1, TRFR

Molecular Weight: 85kDa

Gene ID: 7037

HGNC: 7037

UniProt: P02786

Pathways: Transition Metal Ion Homeostasis