PLAGL1 antibody (AA 118-222)

Catalog No. ABIN1724869

Product Details anti-PLAGL1 Antibody

Target: PLAGL1 (Pleiomorphic Adenoma Gene-Like 1 (PLAGL1))

Binding Specificity: AA 118-222

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PLAGL1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Purpose: PLAGL1 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human PLAGL1 (AA: 118-222) expressed in E. Coli.

Clone: 8D8C5

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-PLAGL1 antibody (ABIN1724869)

Liu, Hsieh, Liu, Chang, Lin, Wang, Huang: "Zac1, an Sp1-like protein, regulates human p21(WAF1/Cip1) gene expression in HeLa cells." in: Experimental cell research, Vol. 317, Issue 20, pp. 2925-37, (2011) (PubMed).

Target Details for PLAGL1

Target: PLAGL1 (Pleiomorphic Adenoma Gene-Like 1 (PLAGL1))

Alternative Name: PLAGL1 (PLAGL1 Products)

Synonyms: PLAGL1 antibody, LOT1 antibody, ZAC antibody, ZAC1 antibody, Lot1 antibody, Zac1 antibody, PLAG1 like zinc finger 1 antibody, uncharacterized LOC100350914 antibody, pleiomorphic adenoma gene-like 1 antibody, PLAGL1 antibody, LOC100350914 antibody, Plagl1 antibody

Background:

Description: This gene encodes a C2H2 zinc finger protein with transactivation and DNA-binding activities. It has been shown to have anti-proliferative properties, and thus thought to function as a tumor suppressor. In addition, overexpression of this gene during fetal development is believed to underlie the rare disorder, transient neonatal diabetes mellitus (TNDM). This gene is imprinted, with preferential expression of the paternal allele in many tissues, however, biallelic expression has been noted in peripheral blood leucocytes. A recent study reports that tissue-specific imprinting results from variable utilization of monoallelic and biallelic promoters. Many transcript variants differing in the 5' UTR and encoding two different isoforms, have been found for this gene.

Aliases: ZAC, LOT1, ZAC1

Molecular Weight: 50.8kDa

Gene ID: 5325

HGNC: 5325

UniProt: Q9UM63