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Dynamin 1-Like antibody (AA 69-213)

DNM1L Reactivity: Human WB, ELISA, IHC Host: Mouse Monoclonal 4E11B11 unconjugated
Catalog No. ABIN1724863
  • Target See all Dynamin 1-Like (DNM1L) Antibodies
    Dynamin 1-Like (DNM1L)
    Binding Specificity
    • 23
    • 11
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 69-213
    Reactivity
    • 50
    • 44
    • 27
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 59
    • 6
    Mouse
    Clonality
    • 59
    • 6
    Monoclonal
    Conjugate
    • 31
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Dynamin 1-Like antibody is un-conjugated
    Application
    • 32
    • 27
    • 17
    • 13
    • 13
    • 11
    • 9
    • 9
    • 4
    • 3
    • 2
    • 2
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Purpose
    DNM1L Antibody
    Purification
    Purified antibody
    Immunogen
    Purified recombinant fragment of human DNM1L (AA: 69-213) expressed in E. Coli.
    Clone
    4E11B11
    Isotype
    IgG1
  • Application Notes
    ELISA: 1/10000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified antibody in PBS with 0.05 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Thomas, Jacobson: "Defects in mitochondrial fission protein dynamin-related protein 1 are linked to apoptotic resistance and autophagy in a lung cancer model." in: PLoS ONE, Vol. 7, Issue 9, pp. e45319, (2012) (PubMed).

    Marsboom, Toth, Ryan, Hong, Wu, Fang, Thenappan, Piao, Zhang, Pogoriler, Chen, Morrow, Weir, Rehman, Archer: "Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension." in: Circulation research, Vol. 110, Issue 11, pp. 1484-97, (2012) (PubMed).

  • Target
    Dynamin 1-Like (DNM1L)
    Alternative Name
    DNM1L (DNM1L Products)
    Background

    Description: The protein encoded by this gene is a member of the dynamin superfamily of GTPases. Members of the dynamin-related subfamily, including the S. cerevisiae proteins Dnm1 and Vps1, contain the N-terminal tripartite GTPase domain but do not have the pleckstrin homology or proline-rich domains. This protein establishes mitochondrial morphology through a role in distributing mitochondrial tubules throughout the cytoplasm. The gene has 3 alternatively spliced transcripts encoding different isoforms. These transcripts are alternatively polyadenylated.

    Aliases: DLP1, DRP1, DVLP, EMPF, VPS1, DYMPLE, HDYNIV, DYNIV-11

    Molecular Weight
    81.9kDa
    Gene ID
    10059
    HGNC
    10059
    UniProt
    O00429
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