IL3RA antibody (AA 200-305)

Catalog No. ABIN1724855

Product Details anti-IL3RA Antibody

Target: IL3RA (Interleukin 3 Receptor, alpha (IL3RA))

Binding Specificity: AA 200-305

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL3RA antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC)

Purpose: IL3RA Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human IL3RA (AA: 200-305) expressed in E. Coli.

Clone: 8E11C5

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-IL3RA antibody (ABIN1724855)

Venkataraman, Aguhar, Kreitman, Yuan, Stetler-Stevenson: "Characteristic CD103 and CD123 expression pattern defines hairy cell leukemia: usefulness of CD123 and CD103 in the diagnosis of mature B-cell lymphoproliferative disorders." in: American journal of clinical pathology, Vol. 136, Issue 4, pp. 625-30, (2011) (PubMed).

Yue, Fu, Wang, Li, Hu, Fu, Shao: "Expression of CD123 and CD114 on the bone marrow cells of patients with myelodysplastic syndrome." in: Chinese medical journal, Vol. 123, Issue 15, pp. 2034-7, (2010) (PubMed).

Target Details for IL3RA

Target: IL3RA (Interleukin 3 Receptor, alpha (IL3RA))

Alternative Name: IL3RA (IL3RA Products)

Synonyms: CD123 antibody, IL3R antibody, IL3RAY antibody, IL3RX antibody, IL3RY antibody, hIL-3Ra antibody, CDw123 antibody, SUT-1 antibody, Cyrl antibody, interleukin 3 receptor subunit alpha antibody, interleukin 3 receptor, alpha chain antibody, IL3RA antibody, Il3ra antibody

Background:

Description: The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found.

Aliases: IL3R, CD123, IL3RX, IL3RY, IL3RAY, hIL-3Ra

Molecular Weight: 43.3kDa

Gene ID: 3563

HGNC: 3563

UniProt: P26951

Pathways: JAK-STAT Signaling