EGFR Mutant (AA 693-893) antibody
(2 references)-
- Target
- EGFR Mutant
-
Binding Specificity
- AA 693-893
- Reactivity
- Human
-
Host
- Mouse
-
Clonality
- Monoclonal
-
Conjugate
- Un-conjugated
-
Application
- ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)
- Purpose
- EGFR mutant Antibody
- Characteristics
- Mutant
- Purification
- Ascitic fluid
- Immunogen
- Purified recombinant fragment of human EGFR mutant (AA: 693-893) expressed in E. Coli.
- Clone
- 5G9B5
- Isotype
- IgG1
-
anti-EGFR Mutant (AA 693-893), (Mutant) antibody
Reactivity: Human ELISA, IHC, FACS, WB Host: Mouse Monoclonal unconjugated
-
- Application Notes
-
ELISA: 1/10000
FCM: 1/200 - 1/400
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Buffer
- Ascitic fluid containing 0.03 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
-
-
: "Impact of epidermal growth factor receptor (EGFR) cell surface expression levels on effector mechanisms of EGFR antibodies." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 189, Issue 11, pp. 5230-9, (2012) (PubMed).
: "Meprin? transactivates the epidermal growth factor receptor (EGFR) via ligand shedding, thereby enhancing colorectal cancer cell proliferation and migration." in: The Journal of biological chemistry, Vol. 287, Issue 42, pp. 35201-11, (2012) (PubMed).
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: "Impact of epidermal growth factor receptor (EGFR) cell surface expression levels on effector mechanisms of EGFR antibodies." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 189, Issue 11, pp. 5230-9, (2012) (PubMed).
-
- Target
- EGFR Mutant
- Background
-
Description: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.
Aliases: ERBB, HER1, mENA, ERBB1, PIG61
- Molecular Weight
- 175kDa
- Gene ID
- 1956
- HGNC
- 1956
- UniProt
- P00533
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